Name | AZ7550 hydrochloride |
Description | AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM). |
In vitro | AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM). |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 1.5 mg/mL (2.8 mM), Sonication and heating are recommended.
|
Keywords | EGFR | ErbB-1 | Epidermal growth factor receptor | HER1 | Drug Metabolite | AZ-7550 Hydrochloride | AZ7550 hydrochloride | AZ7550 Hydrochloride | inhibit | AZ7550 | 1421373-99-0 | AZ-7550 | 1421373-99-0 free base | AZ 7550 Hydrochloride | AZ 7550 | Inhibitor | IGF-1R | AZ-7550 hydrochloride |
Inhibitors Related | Osimertinib | Lidocaine Hydrochloride hydrate | Lapatinib | Afatinib Dimaleate | Erlotinib hydrochloride | Erlotinib | Neratinib | Chalcone | Osimertinib mesylate | Genistein | Khellin | Gefitinib |
Related Compound Libraries | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Inhibitor Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Liver Cancer Compound Library |