| Name | Acyclovir |
| Description | Acyclovir (Aciclovir) is a synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses of the herpesvirus family. |
| Kinase Assay | Total AMPK activity is measured using the method of Dagher et al. AMPK activity is quantified in the resuspended pellet as incorporation of?32P from [γ-32P]ATP (10 GBq/mmol) into a synthetic peptide with the specific target sequence for AMPK, the SAMS peptide. Radioactivity is measured using a liquid scintillation counter. Protein content in the solution containing the resupended (NH4)2SO4 pellet is determined using the Bradford method. |
| In vitro | Acyclovir sensitivity of herpes simplex virus isolates is determined in a plaque-reduction assay in Vero cells. IC50 Values are consistently 2-3 fold lower in B2 compared with the H strain of Vero cells. HSV Type 2 strains are 2-10-fold less sensitive than Type 1 strains[2]. |
| In vivo | low-dose oral acyclovir may be effective in the prevention of HSV infection during OKT3 treatment of seropositive patients. Continuation of acyclovir prophylaxis for two to four weeks following the conclusion of OKT3 therapy may prevent occurrence of delayed infections[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.88 mM), Sonication is recommended.
DMSO : 42.92 mg/mL (190.59 mM), Sonication is recommended.
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | triphosphate | thymidine | RNASynthesis | RNA Synthesis | polymerase | kinase | Inhibitor | inhibit | immunosuppression | HSV | Herpes simplex virus | DNASynthesis | DNA synthesis | DNA Synthesis | DNA | Bacterial | Apoptosis | anti-herpetic | antibody | Antibiotic | Acyclovir |
| Inhibitors Related | Neomycin sulfate | Stavudine | Cysteamine hydrochloride | Kanamycin sulfate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Guanidine hydrochloride | Doxycycline | Tributyrin | Thymidine | Dimethyl sulfoxide | Alginic acid |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | ReFRAME Related Library | Anti-Cancer Clinical Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
