| Name | Acriflavine |
| Description | Acriflavine (Acriflavinium chloride 3,6-Acridinediamine mix) is a papain-like protease (PL(pro)) inhibitor, a fluorescent dye for labeling high molecular weight RNAs, has antimicrobial and anticancer activity, inhibits SARS-CoV-2 and other β-coronaviruses, and can be used for research on leukemia. be used to study leukemia. |
| Animal Research | CML mice are treated daily with acriflavine (8 mg/kg) or PBS via intraperitoneal injection, for 10 days starting from day 7 after bone marrow transplantation [2]. |
| In vitro | A novel candidate drug, Acriflavine, exhibits significant dose-dependent inhibition of A549 cell viability at low concentrations (1, 2, 5, and 10 μM)[1]. |
| In vivo | Nude mice bearing xenografts of A549 cells were intraperitoneally injected with 2 mg/kg ACF daily for six weeks. The results indicate that treatment with ACF leads to a reduction in tumor size[1]. |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 20 mg/mL (77.00 mM)
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| Keywords | Acriflavine |
| Inhibitors Related | Neomycin sulfate | Sulfamethoxazole sodium | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
United States
