| CAS: | 59-66-5 |
| MF: | C4H6N4O3S2 |
| MW: | 222.25 |
| EINECS: | 200-440-5 |
| Product Categories: | Furans;Isotope;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;ACETAMOX;Miscellaneous Enzyme;API;59-66-5 |
| Mol File: | 59-66-5.mol |
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| Acetazolamide Chemical Properties |
| Melting point | 258-259 °C |
| density | 1.610 (estimate) |
| refractive index | 1.6270 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in NH4OH (50 mg/mL), DMSO, Methanol and slightly soluble in Ethanol. |
| pka | 7.2(at 25℃) |
| form | solid |
| color | White to Off-White |
| Water Solubility | <0.1 g/100 mL at 22 ºC |
| λmax | 265nm(H2O)(lit.) |
| Merck | 14,53 |
| BRN | 212994 |
| BCS Class | 4 |
| Stability: | Hygroscopic |
| InChIKey | BZKPWHYZMXOIDC-UHFFFAOYSA-N |
| CAS DataBase Reference | 59-66-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Acetylamino-1,3,4-thiadiazole-5-sulfonamide(59-66-5) |
| EPA Substance Registry System | Acetazolamide (59-66-5) |
| Acetazolamide Usage And Synthesis |
| Description | Acetazolamide is a drug used for the treatment of glaucoma,epilepsy,altitude sickness,periodic paralysis, chronic macular edema, idiopathic intracranial hypertension, andheart failure. It can also been used for the treatment of altitude sickness, increased intracranial pressure and neuromuscular disorders. In addition, it also has significant effect of diuretic. It belongs to the carbonic anhydrase inhibitorfamilies of medication. It works by decreasing the amount ofhydrogen ionsandbicarbonatein the body. |
| References | Forwand, S. A., et al. "Effect of acetazolamide on acute mountain sickness." New England Journal of Medicine279.16(1968):839.
Cox, S. N., E. Hay, and A. C. Bird. "Treatment of chronic macular edema with acetazolamide." Archives of Ophthalmology 106.9(1988):1190.
Supuran, Claudiu T. "Acetazolamide for the treatment of idiopathic intracranial hypertension." Expert Review of Neurotherapeutics15.8(2015):851.
Kassamali, R, and D. A. Sica. "Acetazolamide: a forgotten diuretic agent." Cardiology in Review 19.6(2011):276.
Lucas, M., and M. Brown. "Acetazolamide Reduces Hospital Admissions and Length of Stay in Refractory Heart Failure Patients." Heart Lung & Circulation 20.Suppl 2(2011):S6-S6.
https://www.rxlist.com/acetazolamide-drug.htm
https://en.wikipedia.org/wiki/Acetazolamide |
| Description | Acetazolamide is a weak diuretic with limited use in edema associated with cardiac insufficiency, glaucoma, minor epileptic attacks, and altitude sickness. |
| Chemical Properties | White Solid |
| Originator | Diamox ,Lederle,US ,1953 |
| Uses | Acetazolamide acts as a carbonic anhydrase inhibitor which increases cerebral blood flow. It inhibits water permeability of membranes by interacting with aquaporins. It is used for the medical treatment of glaucoma, epileptic seizure, idiopathic intracranial hypertension, altitude sickness, cystinuria. |
| Uses | carbonic anhydrase inhibitor, diuretic, antiglaucoma |
| Uses | Acetazolamide is used for epilepsy in the absence of attacks and also in conjunction with other antiepileptic drugs. |
| Definition | ChEBI: Acetazolamide is a sulfonamide, a member of thiadiazoles and a monocarboxylic acid amide. It has a role as a diuretic, an anticonvulsant and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a conjugate acid of an acetazolamide(1-). It derives from a hydride of a 1,3,4-thiadiazole. |
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Packing &shipping&Payment
Packing:25kg/drum
Shipping:by sea or by air
Payment:T/T,western union,moneygram
Packaging Details drum
Port:Tianjin
Lead Time :
| Quantity(Kilograms) | 1 - 10000 | >10000 |
| Est. Time(days) | 5 | To be negotiated |
Company information
Hebei Mojin Biotechnology Co., Ltd, Our company is a professional in 4'-Methylacetophenone,Levamisole hydrochloride ,N-Methylformamide and other chemical reagents research and development production enterprises. Our business covers more than 30 countries, most of the big customers come from Europe, America and other countries in the world, we can guarantee the quality and price. In recent decades, with the efforts of all employees, we have established many cooperative companies in shandong, henan, guangdong and other places. Our corporate purpose is based on the market, enhance the strength, take the road of scientific and environmental sustainable development, relying on the country. Technology r & d center, increase the investment in r & d, based on the domestic market, expand the international market, manufacturing quality products, sincere service to the society, into a modern, ecological, scientific and technological enterprise world.
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