| Name | A-3 hydrochloride |
| Description | A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. It inhibits PKC and casein kinase I with Ki values of 47 μM and 80 μM, respectively[1], and also inhibits PKA (Ki=4.3 μM), casein kinase II (Ki=5.1 μM), and myosin light chain kinase (MLCK) (Ki=7.4 μM). |
| In vitro | A-3 hydrochloride competitively inhibits MLC-kinase with respect to ATP, with a Ki value of 7.4 μM. It also competitively inhibits cAMP-dependent protein kinase, cGMP-dependent protein kinase, protein kinase C, casein kinase I, and casein kinase II with ATP, exhibiting Ki values of 4.3 μM, 3.8 μM, 47 μM, 80 μM, and 5.1 μM, respectively[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (12.45 mM), Sonication is recommended.
DMSO : 125 mg/mL (389.14 mM), Sonication is recommended.
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| Keywords | Protein kinase C | Protein kinase A | PKC | PKA | MLC-kinase | kinase | inhibitor | inhibit | CK2 | CK1 | CaseinKinase | Casein Kinase | casein | cAMP | CaMK | Calmodulin-dependent protein kinases | Calmodulin-dependent kinases | calmodulin | A-3 Hydrochloride | A3 Hydrochloride | A3 hydrochloride | A-3 | A 3 Hydrochloride | A 3 hydrochloride | A 3 |
| Inhibitors Related | Darovasertib | α-Vitamin E | Acefylline | Staurosporine | 8-Bromo-cAMP sodium salt | Emodin | Fasudil hydrochloride | Melatonin | CaMKP Inhibitor | Mitoxantrone dihydrochloride | Nifedipine | JAK1/2/3 Inhibitor 1 |
| Related Compound Libraries | Reprogramming Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Anti-Obesity Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | TGF-beta/Smad Compound Library |
United States
