78957-85-4

White Crystalline Solid

Inhibits cAMP and cGMP dependent protein kinases. Also inhibits MLC kinase and protein kinase C

Non-selective casein kinase (CK) inhibitor. A shorter alkyl chain derivative of W-7 that inhibits casein kinase I (Ki = 80 μM), casein kinase II (Ki = 5.1 μM), myosin light chain kinase (Ki = 7.4 μM), protein kinase A (Ki = 4.3 μM), protein kinase C (Ki= 47 μM), and protein kinase G (Ki = 3.8 μM).

CK1: 80 μM (Ki); CK2: 5.1 μM (Ki); PKC: 47 μM (Ki); PKA: 4.3 μM (Ki)