Polymyxin B sulfate NEW

• MOLECULAR FORMULA :

• C43-H82-N16-O12.xH2-O4-S

• MOLECULAR WEIGHT :

• 1701.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Oral

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 790 mg(base)/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intraperitoneal

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 20500 ug(base)/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 59500 ug(base)/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Rodent - mouse

• DOSE/DURATION :

• 5400 ug(base)/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intravenous

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• 8 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

• TYPE OF TEST :

• LDLo - Lowest published lethal dose

• ROUTE OF EXPOSURE :

• Intracerebral

• SPECIES OBSERVED :

• Mammal - dog

• DOSE/DURATION :

• 320 ug/kg

• TOXIC EFFECTS :

• Behavioral - coma

• TYPE OF TEST :

• LD50 - Lethal dose, 50 percent kill

• ROUTE OF EXPOSURE :

• Subcutaneous

• SPECIES OBSERVED :

• Rodent - guinea pig

• DOSE/DURATION :

• 58 mg/kg

• TOXIC EFFECTS :

• Details of toxic effects not reported other than lethal dose value

MUTATION DATA

• TYPE OF TEST :

• Mutation test systems - not otherwise specified

• TEST SYSTEM :

• Yeast - Saccharomyces cerevisiae

• DOSE/DURATION :

• 5 mg/L

• REFERENCE :

• AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 2,36,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81938 No. of Facilities: 152 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 967 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9499 No. of Facilities: 383 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1149 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81938 No. of Facilities: 1842 (estimated) No. of Industries: 19 No. of Occupations: 18 No. of Employees: 173376 (estimated) No. of Female Employees: 145041 (estimated)