Meropenem: Professional Overview
Definition
Meropenem is a broad-spectrum carbapenem antibiotic belonging to the β-lactam class. It is synthetically derived and exhibits potent bactericidal activity by inhibiting bacterial cell wall synthesis.
Function
Meropenem targets a wide range of Gram-positive and Gram-negative bacteria, including multidrug-resistant strains such as Pseudomonas aeruginosa and Klebsiella pneumoniae. Its stability against β-lactamase enzymes enhances efficacy against resistant pathogens.
Applications
Approved for severe infections, meropenem is indicated for:
· Complicated intra-abdominal infections
· Pneumonia (hospital-acquired and ventilator-associated)
· Urinary tract infections
· Septicaemia
· Febrile neutropenia management