| Name | Ionomycin |
| Description | Ionomycin is a calcium ion carrier and an antibiotic that binds to calcium ions (Ca2+). The main function of Ionomycin is to induce cellular responses by increasing the intracellular calcium ion concentration. In experiments, Ionomycin is typically used to activate calcium-dependent processes, such as apoptosis and enzyme activity. |
| In vitro | METHODS: LCLC 103H cells were treated with Ionomycin and analyzed using DNA and protein.
RESULTS: Ionomycin induces DNA fragmentation and PARP lysis into an 85-kDa fragment of typical caspase-mediated apoptosis. [1] |
| In vivo | METHODS: To investigate the activation of immune cells by Ionomycin, PMA and Ionomycin were used to activate CD4+CD25- T cells in mice to generate inductive regulatory T cells (iTreg), and their functions were tested in a mouse model of inflammatory bowel disease (IBD).
RESULTS: iTreg cells activated by Ionomycin could significantly alleviate the symptoms of IBD mouse models, including weight loss and reduced disease activity scores. [2]
METHODS: To study the role of calcium signaling in embryonic development, Ionomycin was added to the mouse embryo culture medium.
RESULTS: Calcium signaling plays a key role in embryonic cell migration and morphogenesis. [3] |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 90 mg/mL (126.94 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (4.65 mM), Sonication is recommended.
DMSO : 90 mg/mL (126.94 mM), Sonication is recommended.
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| Keywords | Ionomycin | CalciumChannel | Calcium ionophore | Calcium Channel |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | 2,4,6-Tri-tert-butylphenol | Tamoxifen | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Dimethyl sulfoxide | Sodium diacetate | BES |
| Related Compound Libraries | Rare Natural Product Library |
United States
