1. Materials information
Names
| Name | Ambroxol hydrochloride |
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| Synonym | More Synonyms |
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Ambroxol HCl Biological Activity
| Description | Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the prodrug Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2]. |
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| Related Catalog | Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Metabolic Disease Research Areas >> Neurological Disease |
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| In Vivo | Ambroxol hydrochloride (NA-872 hydrochloride; 1, 3, 4, 5 mM for 12 consecutive days in drinking water) results in increased brain glucocerebrosidase activity in wild-type mice, transgenic mice expressing the heterozygous L444P mutation in the murine glucocerebrosidase 1 gene, and transgenic mice overexpressing human α-synuclein[2]. |
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| References | [1]. Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218. [2]. Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. |
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Chemical & Physical Properties
| Boiling Point | 468.6ºC at 760 mmHg |
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| Melting Point | 235 - 240ºC |
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| Molecular Formula | C13H19Br2ClN2O |
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| Molecular Weight | 414.564 |
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| Flash Point | 237.2ºC |
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| Exact Mass | 411.955261 |
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| PSA | 58.28000 |
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| LogP | 4.96100 |
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2. Packaging of materials
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping & Delivery
Provide door to door service
Suitable for goods under 50kg
Delivery: 3-7 days
Cost: low cost
Provide airport to airport service
Suitable for goods over 50kg
Delivery: 3-14 days
Cost: high cost
Provide seaport to seaport service
Suitable for goods over 100kg
Delivery: 2-45 days
Cost: low cost
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