9-Phenylacridine NEW

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Min. Order0.100000001490116KG
Purity98%
Cas No602-56-2
Supply Ability1000KGS
Update time2025-11-25

Zhengzhou Anbu Chem Co.,Ltd

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Chemical Properties

Product Name	9-Phenylacridine
CAS No	602-56-2
EC-No
Min. Order	0.100000001490116KG
Purity	98%
Supply Ability	1000KGS
Release date	2025/11/25

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9-Phenylacridine Basic information

Product Name:	9-Phenylacridine
Synonyms:	9-phenyl-acridin;9-Phenylacridin (9-PA);3-propan-2-yloxy-1-cyclohex-2-enone;phenylacridine;9-PHENYLACRIDINE;9-PA;Acridine, 9-phenyl-;9-Phenylacridine>
CAS:	602-56-2
MF:	C19H13N
MW:	255.31
EINECS:	210-020-3
Product Categories:	Miscellaneous
Mol File:	602-56-2.mol

9-Phenylacridine Chemical Properties

Melting point	184°C
Boiling point	388.54°C (rough estimate)
density	0.9418 (rough estimate)
refractive index	1.6500 (estimate)
storage temp.	Sealed in dry,Room Temperature
pka	5.45±0.10(Predicted)
form	powder to crystal
color	Light yellow to Amber to Dark green
InChI	InChI=1S/C19H13N/c1-2-8-14(9-3-1)19-15-10-4-6-12-17(15)20-18-13-7-5-11-16(18)19/h1-13H
InChIKey	MTRFEWTWIPAXLG-UHFFFAOYSA-N
SMILES	C1C2C(=NC3C(C=2C2=CC=CC=C2)=CC=CC=3)C=CC=1
CAS DataBase Reference	602-56-2(CAS DataBase Reference)
NIST Chemistry Reference	Acridine, 9-phenyl-(602-56-2)
EPA Substance Registry System	Acridine, 9-phenyl- (602-56-2)

Safety Information

Safety Statements	22-24/25
HS Code	2933.99.8210

MSDS Information

9-Phenylacridine Usage And Synthesis

Uses	Research has found that 9-phenylacridine (ACPH) exhibited anticancer activity in cell lines and in vivo animal models. Bioinformatics studies have indicated that it could have topoisomerase I inhibitory activity. It could also act as a PARP 1 inhibitor and was very effective in combination with cisplatin in cell line-based assays. ACPH also satisfied all criteria for a candidate drug from the Lipinski rule and showed good cell uptake. ACPH alone was effective in the A375 melanoma cell line. ACPH could be used as a promising new photosensitizer[1-2]. 9-Phenylacridine is the parent base of chrysaniline or 3,6-diamino-9- phenylacridine, the chief constituent of the dyestuff phosphine. It is commonly used in the electronics industry as a free radical photoinitiator, significantly improving photo speed.
Description	9-Phenylacridine has antitumour activity. It can be used as a photosensitiser and can sensitise UVA-induced DNA damage in vitro and in cells. It also enhances cell killing by UVA. In addition. It is also used in photochemical research and as a raw material for organic synthesis.
Biological Activity	Hansda et al. suggested that a nontoxic dose of 9-Phenylacridine (ACPH) with UVA light can inhibit the proliferation of A375 cells by inducing DNA damage both in in vitro DNA and in cells through photosensitization. Such treatment enhanced the generation of ROS in cells, leading to lipid peroxidation and depletion of GSH. This led to cell cycle arrest at the G2/M phase to promote apoptosis through the mitochondria-mediated pathway. Although there was a slight increase in the small population of cells undergoing death through autophagy by UVA on ACPH pretreatment, primarily UVA+ACPH resulted in cell death through apoptosis. Thus, using ACPH as a photosensitizer in PDT may be contemplated. Applying ACPH topically to target cells and then illuminating them with UVA can minimize the concern of inducing damage to the surrounding normal cells [1].
References	[1] Surajit Hansda, Rita Ghosh, Gargi Ghosh. "9-phenyl acridine photosensitizes A375 cells to UVA radiation." Heliyon (2020): e04733. [2] Rita Ghosh, Dipanjan Guha, Sudipta Bhowmik. "9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells." Molecular and Cellular Biochemistry 361 1–2 (2012): 55–66.

9-Phenylacridine Preparation Products And Raw materials

Raw materials

Acridine, 1,2,3,4-tetrahydro-9-phenyl--->9-Phenyl-9,10-dihydroacridine-->Benzonitrile, 2-(phenylamino)--->Methanone, phenyl[2-(phenylamino)phenyl]--->TRIPHENYLMETHYLAMINE-->DIPHENYLAMINE HYDROCHLORIDE-->DIPHENYLIODONIUM TRIFLUOROMETHANESULFONATE-->Acridine-->Phenylboronic acid-->9-Chloroacridine-->DIPHENYLZINC-->Benzonitrile-->Benzoic acid-->Diphenylamine-->2-Cyclohexen-1-one

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