Name | 9-Phenanthrol |
Description | 9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel. |
In vitro | In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1]. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 19 mg/mL (97.82 mM), Sonication is recommended. Ethanol : 9 mg/mL (46.34 mM), Sonication is recommended.
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Keywords | TRPVChannel | TRPV Channel | TRPM4 | TRPChannel | TRP Channel | Transient receptor potential channels | NSC-50554 | NSC50554 | NSC 50554 | ischemia-reperfusion injury | Inhibitor | inhibit | 9-Phenanthrol | 9Phenanthrol | 9-Hydroxyphenanthrene | 9 Phenanthrol |
Inhibitors Related | (+)-Camphor | Fingolimod hydrochloride | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Capsaicin | trans-Cinnamaldehyde | Methyl salicylate |
Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |