Name | 9-cis-Retinoic Acid |
Description | 9-cis-Retinoic Acid (Alitretinoin) is a derivative of vitamin A. It is a RAR/RXR agonist with anticancer, antitumor, anti-inflammatory, and neuroprotective activities, induces apoptosis, regulates the cell cycle, and can be used to study advanced tumors. |
In vitro | In CA 9-22 and NA cells, 9-cis-Retinoic acid (1 μM, 10 μM; 0 day, 1 day, 3 days, 5 days) significantly decreased proliferation[1]. |
In vivo | In male C57BL/6J mice (6-8 weeks old; 19-22 g), following bile duct ligation, treatment with 9-cis-Retinoic Acid (1 mg/kg; intravenous injection; once daily; for 10 days) significantly decreased serum ALT and AST levels and alleviated hepatic necrosis[3]. |
Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 15 mg/mL (49.93 mM), Sonication is recommended.
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Keywords | 9-cis-Retinoic Acid | 9cisRetinoic Acid | 9 cis Retinoic Acid |
Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |