Dihydrochelerythrine

Common Name

Dihydrochelerythrine

CAS Number

6880-91-7

Molecular Weight

349.380

Density

1.3±0.1 g/cm3

Boiling Point

565.9±50.0 °C at 760 mmHg

Molecular Formula

C21H19NO4

Melting Point

N/A

MSDS

N/A

Flash Point

171.6±27.3 °C

 Use of Dihydrochelerythrine

 
Dihydrochelerythrine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal activity.IC50 value:Target: in vitro: Dihydrochelerythrine showed the highest antifungal activity against B. cinerea Pers, with 98.32% mycelial growth inhibition at 50 μg/mL. Dihydrochelerythrine inhibited spore germination in vitro in a concentration-dependent manner [1]. Dihydrochelerythrine appeared to be less cytotoxic since the viability of cells exposed to 20 microM dihydrochelerythrine for 24h was reduced only to 53%. A dose-dependent induction of apoptosis and necrosis by chelerythrine and dihydrochelerythrine was confirmed by annexin V/propidium iodide dual staining flow cytometry [2]. Dihydrochelerythrine (4) exhibited strong activity against methicillin-resistant Staphylococcus aureus SK1 and moderate activity against Escherichia coli TISTR 780 with MIC values of 8 and 16 μg/mL, respectively [3].