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ChemicalBook Product Catalog Biochemical Engineering Inhibitors protein tyrosine kinase OSI-420

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OSI-420

$ 1.00 /1g

Min. Order1g
Purity99%
Cas No183320-51-6
Supply Ability1ton
Update time2020-01-13

career henan chemical co

6YR

China

Since2014-12-17

AddressRoom 702, Floor 7, Building 10, National University Science Park, High-Tech Zone, Zhengzhou City, H

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Chemical Properties

Product Name	OSI-420
CAS No	183320-51-6
EC-No	200-258-5
Min. Order	1g
Purity	99%
Supply Ability	1ton
Release date	2020/01/13

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Common Name

OSI-420

CAS Number

183320-51-6

Molecular Weight

415.870

Density

N/A

Boiling Point

N/A

Molecular Formula

C21H22ClN3O4

Melting Point

N/A

MSDS

N/A

Flash Point

N/A

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Use of OSI-420

Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.

Properties
Spectrum

Names

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Name

2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol,hydrochloride

Synonym

More Synonyms

OSI-420 Biological Activity

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Description

Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor.

Related Catalog

Research Areas >> Cancer

In Vivo

Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinib clearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmethyl Erlotinib is <5% relative to total plasma concentration[1].

References

[1]. Meany HJ, et al. The plasma and cerebrospinal fluid pharmacokinetics of erlotinib and its active metabolite (OSI-420) after intravenous administration of erlotinib in non-human primates. Cancer Chemother Pharmacol. 2008, 62(3), 387-392.

Chemical & Physical Properties

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Molecular Formula

C21H22ClN3O4

Molecular Weight

415.870

Exact Mass

415.129883

PSA

85.73000

LogP

3.62600

Synonyms

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OSI-420

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Company Profile Introduction

Established in 2014,Career Henan Chemical Co. is a manufacturerspecializing in the sale of fine chemicals. Mainly deals in the sales of: Pharmaceutical intermediates OLED intermediates： Pharmaceutical intermediates; OLED intermediates;