| Name | 8-Bromo-cGMP sodium |
| Description | 8-Bromo-cGMP sodium is a PKG activator, a membrane-permeable analog of cGMP. 8-Bromo-cGMP sodium has pain-relieving and vasodilatory effects, significantly inhibits Ca2+ macroscopic currents, and inhibits high K+-stimulated insulin release. |
| In vitro | 8-Bromo-cGMP sodium (1 µM-0.1 mM) can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[1]
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.[2]
8-Bromo-cGMP sodium (1-100 μM; 8 h) increases the resistance of LLC-PK1 cells to CsA toxicity in concentration-dependently.[2] |
| In vivo | 8-Bromo-cGMP sodium (0.3, 1, 3 nM; intrathecal administration; 10 min before the test; male ICR mice) significantly increases tail-flick latency in Vincristine-treated mice to the levels observed in vehicle-treated naive mice in a dose-dependent manner.[3] Additionally, 8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) induces vasodilator responses in WT littermates and eNOS-Tg mice in the C57BL/6 background (19-35 g).[4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 101 mg/mL (226.41 mM), Sonication is recommended.
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| Keywords | PKG | CalciumChannel | Calcium Channel | Ca2+ | 8-Bromo-cGMP sodium | 8BromocGMP sodium | 8 Bromo cGMP sodium |
| Inhibitors Related | Nisoldipine | Diltiazem hydrochloride | Cromolyn sodium | L-Ascorbic acid | L-Phenylalanine | D-Menthol | Ethyl cinnamate | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Methyl homoveratrate | Otilonium bromide |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Calcium Channel Compound Library | Neuroprotective Compound Library | Anti-Cardiovascular Disease Compound Library | Metabolism Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library |
United States
