1-AZAKENPAULLONE

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1-AZAKENPAULLONE Basic information

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Product Name:

1-AZAKENPAULLONE

Synonyms:

InSolution 1-Azakenpaullone - CAS 676596-65-9 - Calbiochem;1-AZAKENPAULLONE;9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;Pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 9-broMo-7,12-dihydro-;1-Azakenpaullone 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one;InSolution? 1-Azakenpaullone;1-Azakenpaullone - CAS 676596-65-9 - Calbiochem

CAS:

676596-65-9

MF:

C15H10BrN3O

MW:

EINECS:

Product Categories:

All Inhibitors;Inhibitors;-;Protein Kinase Inhibitors and Activators

Mol File:

676596-65-9.mol

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1-AZAKENPAULLONE Chemical Properties

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Melting point

>290°C (dec.)

Boiling point

648.8±50.0 °C(Predicted)

density

1.655±0.06 g/cm3(Predicted)

storage temp.

-20°C Freezer

solubility

DMSO: >10mg/mL

pka

13.36±0.20(Predicted)

form

Tan solid

color

gray-brown

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1-AZAKENPAULLONE Usage And Synthesis

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Chemical Properties

Tan Solid

Uses

A selective inhibitor of glycogen synthase kinase-3β.

Enzyme inhibitor

This cell-permeable protein kinase inhibitor (FW = 328.17 g/mol; CAS 676596-65-9: Solubility: 66 mg/mL DMSO; <1 mg/mL H2O), also named 9-bromo-7,12-dihydro-pyrido[3,2’:2,3]azepino[4,5-b]indol-6(5H)-one, selectively and potently targets glycogen synthase kinase 3β, or GSK3β (IC50 = 18 nM) with 100x less inhibitory action against cyclin-dependent kinases (CDKs). 1-Azakenpaullone has become a gold standard for GSK3 inhibition.

Product Name	1-AZAKENPAULLONE
CAS No	676596-65-9
EC-No	200-258-5
Min. Order	1KG
Purity	95--99%
Supply Ability	1ton
Release date	2020/01/05

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