SB 415286

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Product Name:

SB 415286

Synonyms:

1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)aMino]-4-(2-nitrophenyl)-;3-[(3-CHLORO-4-HYDROXYPHENYL)AMINO]-4-(2-NITROPHENYL)-1H-PYRROL-2,5-DIONE;3-[(3-CHLORO-4-HYDROXYPHENYL)AMINO]-4-(2-NITROPHENYL)-1H-PYRROLE-2,5-DIONE;SB 415286

CAS:

264218-23-7

MF:

C16H10ClN3O5

MW:

359.72

EINECS:

Product Categories:

-;PI3K/Akt/mTOR;Inhibitors;Akt;mTOR;PI3K;Protein Kinase

Mol File:

264218-23-7.mol

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SB 415286 Chemical Properties

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density

1.647

storage temp.

−20°C

solubility

DMSO: 16 mg/mL

form

Yellow Solid.

color

yellow to orange

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Safety Information

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Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

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SB 415286 Usage And Synthesis

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Definition

ChEBI: A member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively.

Biological Activity

Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K i = 31 nM for GSK-3 α ); competes with ATP. Has minimal activity against 24 other protein kinases (IC 50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Product Name	SB 415286
CAS No	264218-23-7
EC-No
Min. Order	1g
Purity	99%
Supply Ability	200kg
Release date	2019/12/27

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