GNE 7915

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Product Name:

GNE 7915

Synonyms:

GNE 7915;[4-[[4-(Ethylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2-fluoro-5-methoxyphenyl]-4-morpholinylmethanone;GNE-7915, >=98%;(4-((4-(Ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morphol;(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone

CAS:

1351761-44-8

MF:

C19H21F4N5O3

MW:

443.3953528

EINECS:

Product Categories:

api;Inhibitors

Mol File:

1351761-44-8.mol

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GNE 7915 Chemical Properties

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Boiling point

629.9±65.0 °C(Predicted)

density

1.404±0.06 g/cm3(Predicted)

pka

2.80±0.10(Predicted)

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Safety Information

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MSDS Information

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GNE 7915 Usage And Synthesis

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Uses

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE-7915 is a selective, brain-penetrable LRRK2 inhibitor (Kis = 2 and 18.7 nM in biochemical and cell-based assays, respectively). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 20 nM in vivo.[Cayman Chemical]

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GNE 7915 Preparation Products And Raw materials

Product Name	GNE 7915
CAS No	1351761-44-8
EC-No
Min. Order	1g
Purity	99%
Supply Ability	20kg
Release date	2019/12/24

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