Chemical Properties
White Crystalline Solid
Uses
An antibiotic produced by Streptomyces lincolnensis. Antibacterial
Uses
Lincomycin is a polar, water soluble, broad spectrum antibiotic first isolated from Streptomyces licolnensis by researchers at Upjohn in 1962. Lincomycin was the first of a unique structural class, the lincosamides, containing a rare amino acid, 4-propyl-N-methylproline, coupled to an equally rare aminomethylthio-octopyranoside sugar. Lincomycin and semi-synthetic analogues are often incorrectly considered to be aminoglycosides but share little or no structural similarity. Lincomycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Lincomycin acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Lincomycin has been extensively studied with over 7,000 literature citations.
Definition
ChEBI: A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.
Brand name
Lincocin (Pharmacia & Upjohn).
Contact allergens
Lincomycin is an antibiotic of the lincosanide group，active against Gram-positive bacteria. Occupational exposure occurs in poultry and pig breeders
Veterinary Drugs and Treatments
Lincomycin has dosage forms approved for use in dogs, cats, swine, and in combination with other agents for chickens. Because clindamycin is generally better absorbed, more active, and probably less toxic, it has largely supplanted the use of lincomycin for oral and injectable therapy in small animals, but some clinicians believe that clindamycin does not offer enough clinically significant improvements over lincomycin to justify its higher cost. For further information, refer to the Pharmacology or Doses sections.
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