| Name | 7-Epi 10-desacetyl paclitaxel |
| Description | 7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells. |
| Cell Research | The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1]. |
| In vitro | 7-Epi-10-deacetyltaxol(EDT) exhibited significant in vitro cytotoxicity in HepG2 cells.Nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT.?Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle.?Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 8.11 mg/mL (9.99 mM)
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| Keywords | 7Epi 10desacetyl paclitaxel | 7 Epi 10 desacetyl paclitaxel | 7-Epi 10-desacetyl paclitaxel | Inhibitor | inhibit |
| Inhibitors Related | Methotrexate | Mertansine | Doxorubicin hydrochloride | Daunorubicin hydrochloride | Exatecan | Camptothecin | Methotrexate disodium | Dexamethasone | Fluticasone (propionate) | Paclitaxel | Budesonide | Exatecan Mesylate |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Natural Product Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Tibetan medicine Compound Library |
United States
