| Name | 10-Deacetyl-7-xylosyl paclitaxel |
| Description | 10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. |
| In vitro | 10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1]. |
| In vivo | 10-Deacetyl-7-xylosyl paclitaxel is an active compound used in traditional Chinese medicine to treat cancer.10-Deacetyl-7-xylosyl paclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 10-Deacetyl-7-xylosyl paclitaxel transport (16.3±6.3×10 (-6)cm/s; n=3) suggests that the drug may still be effectively absorbed in the intestinal tract[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 25 mg/mL (26.48 mM)
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| Keywords | inhibit | 10-Deacetyl-7-xylosyl paclitaxel | 10Deacetyl7xylosyl paclitaxel | Microtubule/Tubulin | ADC Payload | 10 Deacetyl 7 xylosyl paclitaxel | ADC Cytotoxin | Inhibitor |
| Inhibitors Related | Methotrexate | Flubendazole | Mebendazole | N-Phenylbenzylamine | Camptothecin | 4-Isopropoxybenzoic acid | Oxfendazole | Dexamethasone | Methylene Blue trihydrate | Griseofulvin | Paclitaxel | 4'-Demethylepipodophyllotoxin |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Microtubule-Targeted Compound Library | Natural Product Library | Saccharide and Glycoside Natural Product Library | Natural Product Library for HTS | Anti-Cancer Active Compound Library |
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