RG108/RG-108

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RG108 Basic information

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Product Name:

RG108

Synonyms:

RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;N-Phthaloyl-L-tryptophan;(S)-2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-, (αS)-;N-Phthaloyl-L-tryptophan (S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)propanoic acid;DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan

CAS:

48208-26-0

MF:

C19H14N2O4

MW:

334.33

EINECS:

Product Categories:

Epigenetics;Inhibitors;DNA Methyltransferase Inhibitor

Mol File:

48208-26-0.mol

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RG108 Chemical Properties

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Melting point

192-194℃

storage temp.

Store at RT

solubility

DMSO: >10mg/mL

form

powder

color

yellow

Sensitive

Light Sensitive

CAS DataBase Reference

48208-26-0

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Safety Information

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WGK Germany

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MSDS Information

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RG108 Usage And Synthesis

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Uses

DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro). It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.

Biological Activity

Non-nucleoside DNA methyltransferase inhibitor that blocks the enzyme active site. Inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity. Demethylates and reactivates epigenetically silenced tumor suppressor genes.

Product Name	RG108/RG-108
CAS No	48208-26-0
EC-No
Min. Order	1KG
Purity	98%
Supply Ability	20kg
Release date	2019/09/06

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