Ridaforolimus

Product Name:

Ridaforolimus

Synonyms:

AP 23573, MK 8669, 42-DiMethylphosphinate-rapaMycin;RapaMycin,42-(diMethylphosphinate) (9CI);deforolimus 572924-54-0;572924-54-0;Deforolimus (AP23573)42-;Deforolimus, 98%, a potent and selective mTOR inhibitor;42-(Dimethylphosphinate)rapamycin;Deforolimus

CAS:

MF:

C53H84NO14P

MW:

990.214

EINECS:

 

Product Categories:

Inhibitors;Akt;Intermediates & Fine Chemicals;Pharmaceuticals;mTOR;PI3K

Mol File:

572924-54-0.mol

 

Ridaforolimus Chemical Properties

Melting point 

95-98°C

storage temp. 

Hygroscopic, -20?C Freezer, Under Inert Atmosphere

 

Safety Information

MSDS Information

 

Ridaforolimus Usage And Synthesis

Chemical Properties

Off-White Solid

Uses

An immunosupressant and is currently being investigated for use in cancer treatments. Ridaforolimus may act as a regulator of protein synthesis, cell proliferation, cell cycle progression and cell survival. Ridaforolimus, was formerly known as Deforolimus.

Uses

Ridaforolimus is a semisynthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a dimethylphosphinate moiety. Like all tacrolimus analogues, ridaforolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing its interaction with target proteins. Ridaforolimus is extensively cited in the literature with over 70 citations.

Definition

ChEBI: A semisynthetic derivative that is sirolimus in which hydroxy group attached to the cyclohexyl moiety has been converted to the corresponding dimethylphosphinate.