What’s Hyaluronic acid ?
Hyaluronic acid is a mucopolysaccharide based on N-acetylglucosamine and glucuronic acid disaccharide repeated unit. Hyaluronic acid is widely presented in soft connective tissues of human and animals such as intercellular substance, vitreous body, umbilical cord, skin, joint synovia and cock' s comb. Its molucule weight range from tens of thousands to multi-million, main physiological function is moisture, lubrication and osmoregulation.
Product Types
1. Food supplements:
Hyaluronic Acid through the oral administration after the digestion absorption, increases in vivo Hyaluronic Acid synthesis the precursor, causes in the skin and other organization's Hyaluronic Acid resultant quantity increases, thus enables the skin the water retention property to increase, rich elasticity, wrinkle reduction.
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Specification\Name
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Food Grade Hyaluronic Acid
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Characters
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White or straw yellow powder
|
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Hyaluronic Acid (dry basis)
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90%-105%
|
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Glucuronic acid
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≥42.0%
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PH(0.1% Water Solution)
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6.0-8.0
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Molecular Weight
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(0.8-2.0)*106
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Protein
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≤ 0.1%
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Transparency (0.1% Solution)
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≥99%
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Residue on Ignition
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≤20
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Loss on drying
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≤10.0%
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Heavy metals (as Pb)
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≤ 20ppm
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Arsenic
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≤2ppm
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Bacteria count
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≤ 100CFU/g
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Mold & Yeast
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≤10CFU/g
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|
Salmonella
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Negative
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Escherichia coli
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Negative
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2. Cosmetics applications:
Hyaluronic Acid has outstanding moisture keeping ability, thus called Natural Moisturing Factor in the world. Hyaluronic Acid is a common ingredient in skin-care products, which can be used as a very effective topical humectant, which can be used for facial wrinkles, reduction of folds and wrinkles, and removal of scars.
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Items
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Specifications
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|
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Cosmetic Grade HA (Low Molecular Weight )
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Cosmetic Grade HA (Middle Molecular Weight )
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Cosmetic Grade HA (High Molecular Weight )
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Characters
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White or off-white powder
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White or off-white powder
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White or off-white powder
|
|
Hyaluronic Acid (dry basis)
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90%-105%
|
90%-105%
|
90%-105%
|
|
PH(0.1% Water Solution)
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6.0-7.5
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6.0-7.5
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6.0-7.5
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Molecular Weight
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10K Da - 1,000K Da
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1,000K Da - 1,800K Da
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≥1,800K Da
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Glucuronic acid
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≥45.0%
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≥45.0%
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≥45.0%
|
|
Protein
|
≤0.08%
|
≤0.08%
|
≤0.08%
|
|
Heavy metals (as Pb)
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≤20ppm
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≤20ppm
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≤20ppm
|
|
Loss on drying
|
≤10.0%
|
≤10.0%
|
≤10.0%
|
|
Residue on Ignition
|
≤20
|
≤20
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≤20
|
|
Bacteria count
|
≤100cfu/g
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≤100cfu/g
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≤100cfu/g
|
|
Mold & Yeast
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≤10cfu/g
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≤10cfu/g
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≤10cfu/g
|
|
Salmonella
|
Negative
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Negative
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Negative
|
|
Escherichia coli
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Negative
|
Negative
|
Negative
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3. Medical applications:
1). Used in eye surgery, such as corneal transplantation, cataract surgery, glaucoma surgery, and surgery to repair retinal detachment.
2). Treat osteoarthritis of the knee. They are administered as a course of injections into the knee joint, which are believed to supplement the viscosity of the joint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect.
3). Applied in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the Hyaluronic Acid to facilitate cell migration into the wound.
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Specification\Name
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Eye Drop Grade Hyaluronic Acid
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Characters
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White hygroscopic powder or granule
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Hyaluronic Acid (dry basis)
|
90%-105%
|
|
Glucuronic acid
|
≥45.0%
|
|
PH(0.1% Water Solution)
|
6.0-7.5
|
|
Molecular Weight
|
(0.8-2.0)*106
|
|
Intrinsic viscosity
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≥1600(on the dries basis )
|
|
Residue on Ignition
|
≤20%
|
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Protein
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≤0.1%
|
|
Transparency (0.1% Solution)
|
≥99%
|
|
Loss on drying
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≤8.0%
|
|
Heavy metals (as Pb)
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≤ 20ppm
|
|
Arsenic
|
≤2ppm
|
|
Bacteria Endotoxin
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≤0.5 EU/mg
|
|
Hemolysis
|
Negative
|
|
Viable Hemolytical Streptococci
|
Negative
|
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Bacteria count
|
≤10CFU/g
|
|
Mold & Yeast
|
≤10CFU/g
|
|
Pseudomonas aeruginosa
|
Negative
|
|
Staphylococcus aureus
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Negative
|
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Specification\Name
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Injection Grade Hyaluronic Acid
|
|
Characters
|
White or almost white powder
|
|
Hyaluronic Acid (dry basis)
|
95.0-105.0%
|
|
600nm ( 1→300 )
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≤ 0.01
|
|
260nm ( 1→300 )
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≤ 0.5
|
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pH(0.1% Water Solution)
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5.0-8.5
|
|
Transparency (0.1% Solution)
|
≥ 99%
|
|
Loss on drying
|
≤10.0%
|
|
Protein
|
≤ 0.1%
|
|
Heavy metals (as Pb)
|
≤ 20ppm
|
|
Chlorides
|
≤ 0.5%
|
|
Intrinsic viscosity
|
Practical value
|
|
Iron
|
≤ 80ppm
|
|
Bacteria count
|
≤ 10CFU/g
|
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Bacteria Endotoxin
|
≤0.05 EU/mg
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Suggestion
|
HA with different M.W
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Application
|
|
0.8 million daltons
|
For facial cleanser and liquid agent
|
|
1~1.3 million daltons
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Cream, gel, skin emulsion and skin milk
|
|
1.3~1.5 million daltons
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Eye care products like eye cream
|
China
