Raloxifene

$ 3.00 /3ASSAYS

Min. Order1KG
Purity99%
Cas No249296-44-4
Supply Ability100kg
Update time2019-07-10

career henan chemical co

7YR

China

Chemical Properties

Product Name	Raloxifene
CAS No	249296-44-4
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	100kg
Release date	2019/07/10

Varenicline Basic information

Product Name:	Varenicline
Synonyms:	Varenicline Impurity;VARENICLINE;7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine;Vareniclene;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-;Varenicline free base;Chantix;Cp 526555
CAS:	249296-44-4
MF:	C13H13N3
MW:	211.26
EINECS:
Product Categories:	API intermediates;API
Mol File:	249296-44-4.mol

Varenicline Chemical Properties

Safety Information

Hazardous Substances Data

249296-44-4(Hazardous Substances Data)

MSDS Information

Varenicline Usage And Synthesis

Description	Varenicline, a partial agonist of the a4b2 nicotinic receptor, is a first-in-class drug launched by Pfizer as an aid to smoking cessation treatment. Varenicline exhibits dual action by decreasing craving and withdrawal symptoms, and by decreasing the reinforcement associated with smoking. The addictive properties of nicotine are thought to be mediated in part through its action as an agonist at α4β2 neuronal nicotinic acetylcholine receptors (nAChRs). Activation of α4β2 receptors by nicotine increases the release of dopamine in the mesolimbic system, an effect that is shared by most drugs of abuse. As nicotine levels decrease, dopamine levels decline, which in turn stimulates the urge to smoke. Additionally, a reduced dopaminergic tone due to abstinence from smoking stimulates craving and the withdrawal syndrome. A partial agonist of α4β2 receptors such as varenicline is expected to elicit a moderate and sustained increase in dopamine levels to relieve craving and withdrawal symptoms. In addition, by competitively binding to a4b2 receptors and inhibiting nicotineinduced dopaminergic activation, a partial agonist could attenuate the pharmacologic reward associated with smoking.
Originator	Pfizer (US)
Uses	Smoking cessation (selective nicotinic receptor modulator).
Definition	ChEBI: An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.
Brand name	Chantix (Pfizer).

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