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English name: Nilotinib
CAS No. : 641571-10-0
Minor: C28H22F3N7O
Son: 529.52
Fold the shoot rate: 1.65
Inchi: Inchi = 1 / C28H22F3N7O/c1-17-5-6-19 (10 to 25 (17) : 37-27-33-9-7-24 (36-27), 33-9-7-8-32-14 and 20) 26 (39), 35-22-11-21 (28, 29, 30, 31) 12-23 (13-22) 38-15-18 (2) 34-16-38 / h3-16 H, 1-2 h3 (H, 35 33) 6 (H, 33,36,37)
Secret: 1.36 g/cm3
Outside view: gray solid
Storage conditions: 2-8 ° C
1, the treatment of newly diagnosed Philadelphia chromosome positive (Ph +) in the chronic phase of adult chronic myelogenous leukemia.
2, treatment of Philadelphia chromosome positive in radically increasing stage and accelerating stage of chronic myelogenous leukemia.
3, has been treated with interferon treatment in chronic phase CML.
4, treatment of bone marrow suppression or recurrence after treatment with interferon invalid pediatric chronic myelogenous leukemia.
5, KIT (CD117) positive surgical treatment or metastatic malignant gastrointestinal stromal tumor.
Adverse reactions: in 438 cases of patients with the Nile for safety study of oral preparation. Grade 3 or 4 of the most common adverse reactions mainly hematology aspect, such as neutral leukopenia and thrombocytopenia. Liver function test is bilirubin, esterase and blood glucose, often for temporary and after can recover. These cases are easy processing, rarely lead to drug withdrawal. Pancreatitis < 1%. The hematology drug adverse reactions caused by common for drug rash, pruritus, nausea, fatigue, headache, constipation and diarrhea, usually for mild to moderate severity
Storage conditions: 2-8 ° C
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