1,1'-Carbonyldiimidazole Basic information
| Product Name: |
1,1'-Carbonyldiimidazole |
| Synonyms: |
carbonylimidazole;1,1'-CARBONYLDIIMIDAZOLE (CDI);CARBONYLDIIMIDAZOLE N,N;N,N'-Carbonyl diimidazole (CDI);CDI (N,N'-Carbonyldiimidazole);1,1-Carbonyldiimidazole99%;N,N'-Carbonyldiimidazole, 98%+;N,N'-Carbonyldiimidazole,97% |
| CAS: |
530-62-1 |
| MF: |
C7H6N4O |
| MW: |
162.15 |
| EINECS: |
208-488-9 |
| Product Categories: |
-;AMIDE;blocks;BuildingBlocks;Zero-Length Crosslinker;pharma material;Imidazoles;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Peptide Coupling Reagents;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);Peptide Synthesis;Synthetic Organic Chemistry;Peptide;Heterocycles;Intermediates |
| Mol File: |
530-62-1.mol |
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| 1,1'-Carbonyldiimidazole Chemical Properties |
| Melting point |
117-122 °C(lit.) |
| Boiling point |
288.83°C (rough estimate) |
| density |
1.303 g/mL at 25 °C |
| refractive index |
n20/D1.434 |
| storage temp. |
2-8°C |
| solubility |
Soluble in dimethylformamide. |
| form |
Crystalline Powder |
| color |
White to light cream |
| PH |
7.7 (50g/l, H2O, 20℃) |
| Sensitive |
Moisture Sensitive |
| Merck |
14,1819 |
| BRN |
6826 |
| Stability: |
Stable, but moisture-sensitive. Incompatible with acids, strong oxidizing agents, water. |
| InChIKey |
PFKFTWBEEFSNDU-UHFFFAOYSA-N |
| CAS DataBase Reference |
530-62-1(CAS DataBase Reference) |
| EPA Substance Registry System |
1H-Imidazole, 1,1'-carbonylbis-(530-62-1) |
| Hazard Codes |
C,Xi,Xn |
| Risk Statements |
22-34-36/37/38-40-36/38 |
| Safety Statements |
26-36/37/39-45-37/39-27-36/37 |
| RIDADR |
UN 3263 8/PG 2 |
| WGK Germany |
2 |
| F |
10-21 |
| Hazard Note |
Harmful/Corrosive/Moisture Sensitive |
| TSCA |
T |
| HazardClass |
8 |
| PackingGroup |
III |
| HS Code |
29332990 |
| Toxicity |
LD50 orally in Rabbit: 1071 mg/kg |
| Provider |
Language |
| 1,1'-Carbonyldiimidazole |
English |
| ACROS |
English |
| SigmaAldrich |
English |
| ALFA |
English |
| |
| 1,1'-Carbonyldiimidazole Usage And Synthesis |
| Chemical Properties |
White crystalline powder |
| Uses |
Used in the synthesis of peptides. Contains up to 10% imidazole. |
| Uses |
peptide coupling reagent |
| Uses |
CDI is mainly employed to convert alcohols and amines into carbamates, esters, and ureas. It is also used in the synthesis of peptides and nucleoside triphosphates. |
| Uses |
In the synthesis of peptides. Reacts readily with carboxylic acids to form acyl imidazoles; subsequent reaction with amines to form amides goes smoothly. |
| Purification Methods |
Crystallise it from *benzene or tetrahydrofuran in a dry-box and store it dry. [Hearn Methods Enzymol 135 102 1987, Beilstein 23/4 V 245.] |
| |
| 1,1'-Carbonyldiimidazole Preparation Products And Raw materials |
| Preparation Products |
6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE-->1-Boc-4-(aminomethyl)piperidine-->2,8-DICHLOROPYRIMIDO[5,4-D]PYRIMIDINE-->2-Ethylpiperazine-->4-N-BOC-Aminopiperidine-->5-BROMO-2-BENZOXAZOLINONE 97-->Pazufloxacin-->isoglutamine-->6-Chloronicotinonitrile-->4-Cyanopiperidine-->1,3-THIAZOLIDIN-2-ONE-->2-AMINO-5-BROMOBENZAMIDE-->3-(1H-INDOL-3-YL)-1-PROPANAMINE-->3-BROMOTHIOPHENE-2-CARBOXAMIDE-->2,3-DIAMINONAPHTHALENE-->1-Boc-2-Methylpiperazine-->5-AMINO-3-PYRIDINECARBONITRILE-->5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97%-->2-(Boc-aminomethyl)-piperidine-->4-(Boc-Aminomethyl)piperidine-->8-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE-->7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID AMIDE-->5-BROMOTHIOPHENE-2-CARBONITRILE-->1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE-->4-AMINOMETHYL-BENZAMIDE-->3-oxo-3-phenyl-propanamide-->Progabide-->3-Cyanomethylthiophene-->N-Heptafluorobutyrylimidazole |
| Raw materials |
Imidazole |
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