Proflavine hydrochloride

Manufacturer 
RTECSAR8700000 
SPECTRUM CHEMICAL MFG. CORP. 
TSCATSCA 8(b) inventory: No 
products were found. 
Commercial Name(s)Not available. 
CI# Not available. 
Synonym3,6-Acridinediamine hydrochloride 
IN CASE OF EMERGENCY 
Not available. 
Chemical Name 
Chemical FamilyNot available.CALL (310) 516-8000 
C13H11N3.HCl 
Chemical Formula 
SPECTRUM CHEMICAL MFG. CORP. 

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Section 2.Composition and Information on Ingredients
Exposure Limits 
TWA (mg/m3)STEL (mg/m3) CEIL (mg/m3) 
NameCAS #% by Weight 
1) Proflavine HCl952-23-8100 
Toxicological DataNot applicable. 
on Ingredients 

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Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of 
inhalation. 
Potential Chronic HealthHazardous in case of ingestion. 
Slightly hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation. 
Effects 
CARCINOGENIC EFFECTS: Not available. 
MUTAGENIC EFFECTS: Not available. 
TERATOGENIC EFFECTS: Not available. 
DEVELOPMENTAL TOXICITY: Not available. 
Proflavine HCl 

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Section 4. First Aid Measures
Eye ContactNo known effect on eye contact, rinse with water for a few minutes. 
Skin ContactAfter contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin 
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. 
Cover the irritated skin with an emollient. If irritation persists, seek medical attention. Wash contaminated 
clothing before reusing. 
Serious Skin ContactNot available. 
InhalationAllow the victim to rest in a well ventilated area. Seek immediate medical attention. 
Serious InhalationNot available. 
IngestionDo not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not 
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention. 
Serious IngestionNot available. 

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature. 
Auto-Ignition Temperature Not available. 
Flash PointsNot available. 
Flammable LimitsNot available. 
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). 
Products of Combustion 
Fire Hazards in Presence of Not available. 
Various Substances 
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. 
of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. 
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. 
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. 
Special Remarks onNot available. 
Fire Hazards 
Special Remarks on Explosion Not available. 
Hazards 

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Section 6. Accidental Release Measures
Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by 
spreading water on the contaminated surface and dispose of according to local and regional authority 
requirements. 
Large Spill 
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water 
on the contaminated surface and allow to evacuate through the sanitary system. 
Proflavine HCl 

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Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the 
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. 
StorageKeep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly 
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat 
and away from strong oxidizing agents. 

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Section 8. Exposure Controls/Personal Protection
Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below 
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to 
airborne contaminants below the exposure limit. 
Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. 
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used 
a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist 
BEFORE handling this product. 
Exposure LimitsNot available. 

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid.Not available. 
Odor 
TasteNot available. 
Molecular Weight245.71 g/mole 
ColorNot available. 
pH (1% soln/water)Not available. 
Boiling PointNot available. 
Melting PointNot available. 
Critical TemperatureNot available. 
Not available. 
Specific Gravity 
Vapor PressureNot applicable. 
Not available. 
Vapor Density 
VolatilityNot available. 
Not available. 
Odor Threshold 
Water/Oil Dist. Coeff.Not available. 
Ionicity (in Water)Not available. 
Not available. 
Dispersion Properties 
SolubilityNot available. 

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Section 10. Stability and Reactivity Data
StabilityThe product is stable. 
Instability TemperatureNot available. 
Conditions of InstabilityNot available. 
Incompatibility with variousNot available. 
substances 
CorrosivityNon-corrosive in presence of glass. 
Proflavine HCl 
Not available. 
Special Remarks on 
Reactivity 
Not available. 
Special Remarks on 
Corrosivity 
PolymerizationNo. 

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Section 11. Toxicological Information
Routes of EntryIngestion. 
Toxicity to AnimalsLD50: Not available. 
LC50: Not available. 
Chronic Effects on Humans Not available. 
Other Toxic Effects on 
Hazardous in case of ingestion. 
HumansSlightly hazardous in case of skin contact (irritant), of inhalation. 
Special Remarks on 
Not available. 
Toxicity to Animals 
Special Remarks onNot available. 
Chronic Effects on Humans 
Special Remarks on otherNot available. 
Toxic Effects on Humans 

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Section 12. Ecological Information
EcotoxicityNot available. 
Not available. 
BOD5 and COD 
Possibly hazardous short term degradation products are not likely. However, long term degradation products may 
Products of Biodegradation 
arise. 
Toxicity of the ProductsThe products of degradation are more toxic. 
of Biodegradation 
Special Remarks on theNot available. 
Products of Biodegradation 

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Section 13. Disposal Considerations
Waste Disposal 

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Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States). 
IdentificationNot applicable. 
Not applicable. 
Special Provisions for 
Transport 
DOT (Pictograms) 
Proflavine HCl 

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Section 15. Other Regulatory Information and Pictograms
No products were found. 
Federal and State 
Regulations 
California 
Proposition 65 
Warnings 
Other RegulationsNot available.. 
WHMIS (Canada) Not controlled under WHMIS (Canada). 
Other Classifications 
DSCL (EEC)This product is not classified according 
to the EU regulations. 
Health Hazard 
HMIS (U.S.A.)1 National Fire Protection 
1 Flammability 
1 Association (U.S.A.) 
Fire Hazard 
1 0 Reactivity 
Health 
Reactivity 
0 
Specific hazard 
Personal Protection 
E 
WHMIS (Canada) 
(Pictograms) 
DSCL (Europe) 
(Pictograms) 
TDG (Canada) 
(Pictograms) 
ADR (Europe) 
(Pictograms) 
Protective Equipment 
Gloves. 
Lab coat. 
Dust respirator. Be sure to use an 
approved/certified respirator or 
equivalent. 
Safety glasses. 
 

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SECTION 16 - ADDITIONAL INFORMATION
N/A 

MOLECULAR FORMULA :

C13-H11-N3.Cl-H

MOLECULAR WEIGHT :

245.73

WISWESSER LINE NOTATION :

T C666 BNJ EZ MZ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

190 mg/kg

TOXIC EFFECTS :

Kidney, Ureter, Bladder - hematuria

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5040 mg/kg/6W-C

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

27 gm/kg/109W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

35 gm/kg/104W-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors

MUTATION DATA

TYPE OF TEST :

Mutation in mammalian somatic cells

TEST SYSTEM :

Rodent - mouse Lymphocyte

DOSE/DURATION :

500 ug/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 204,323,1988 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 24,195,1980 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987