API-2

$ 2.00 /1kg

career henan chemical co

VIP8Y

China

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Chemical Properties

API-2 Basic information

Product Name:	API-2
Synonyms:	API-2;6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE;AKT/PKB SIGNALING INHIBITOR-2;AKT INHIBITOR V;1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE;1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura;1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof;3-amine
CAS:	35943-35-2
MF:	C13H16N6O4
MW:	320.3
EINECS:
Product Categories:	Protein Kinase;Inhibitors;Akt;mTOR;PI3K
Mol File:	35943-35-2.mol

API-2 Chemical Properties

Boiling point	459.21°C (rough estimate)
density	1.2633 (rough estimate)
refractive index	1.7000 (estimate)
storage temp.	Store at RT
solubility	DMSO: >10mg/mL
color	tan
InChIKey	HOGVTUZUJGHKPL-HTVVRFAVSA-N

Safety Information

RTECS

RY8455000

MSDS Information

API-2 Usage And Synthesis

Chemical Properties	Off-White Solid
Uses	Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
Biological Activity	Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

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