| Name | 5-O-Demethylnobiletin |
| Description | 5-O-Demethylnobiletin (5-DEMETHYLNOBILETIN) is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX-2. |
| In vitro | 5-DEMETHYLNOBILETIN promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[1]. |
| In vivo | 5-O-Demethylnobiletinreduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA -induced oedema in mouse paws.The flavone inhibited leukotriene B formation in rat neutrophils and elastase release in human neutrophils, but did not reduce the expression of cyclooxygenase-2 (COX-2) in murine RAW 264.7 macrophages.These experimental results suggest that 5-O-Demethylnobiletinmay actthrough a direct inhibition of 5-LOX, without affecting the expression of COX-2[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.88 mg/mL (10 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.57 mM), Sonication is recommended.
|
| Keywords | LOX | Lipoxygenase | LeukotrieneReceptor | Leukotriene Receptor | Inhibitor | inhibit | 5-O-Demethylnobiletin | 5ODemethylnobiletin | 5 O Demethylnobiletin |
| Inhibitors Related | Montelukast sodium | 2,5-Di-tert-butylhydroquinone | Caffeic Acid | 5-LOX inhibitor | Diethylcarbamazine citrate | Abietic Acid | Resveratrol | NNK | PF-4191834 | Malotilate | 5-Aminosalicylic Acid | ABT-080 |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Miao medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library |
United States
