1. Product information
Names
| Name | 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxychromen-4-one |
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| Synonym | More Synonyms |
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5-O-Demethylnobiletin Biological Activity
| Description | 5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Sideritis tragoriganum, is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4)(LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].5-O-Demethylnobiletin (5-demethylnobiletin) promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent signaling pathways[2]. |
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| Related Catalog | Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Neurological Disease |
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| Target | IC50: 0.1 μM (Lox 5); 0.35 μM (LTB4) (5-O-Demethylnobiletin)[1] |
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| References | [1]. Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42. [2]. Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61(39):9453-63. |
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Chemical & Physical Properties
| Density | 1.304±0.06 g/cm3 |
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| Boiling Point | 601.4±55.0 °C at 760 mmHg |
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| Melting Point | 145-146 ºC |
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| Molecular Formula | C20H20O8 |
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| Molecular Weight | 388.368 |
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| Flash Point | 213.9±25.0 °C |
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| Exact Mass | 388.115814 |
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| PSA | 96.59000 |
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| LogP | 2.10 |
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| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
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| Index of Refraction | 1.583 |
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| Storage condition | 2-8C |
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| Water Solubility | Practically insoluble (0.058 g/L) (25 ºC) |
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Precursor & DownStream
| Precursor 10 | Previous 1/3 Next |
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 CAS#:478-01-3
Nobiletin
 CAS#:654083-34-8
1-(2-hydroxy-3,...
 CAS#:3535-37-3
veratroyl chloride
![(1H-benzo[d][1,2,3]triazol-1-yl)(3,4-dimethoxyphenyl)methanone Structure](https://www.chemsrc.com/caspic/248/333347-81-2.png) CAS#:333347-81-2
(1H-benzo[d][1,...
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| DownStream 1 |
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CAS#:478-01-3
Nobiletin
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Customs
| HS Code | 2914509090 |
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| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
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Synonyms
| 4H-1-Benzopyran-4-one, 2-(3,4-dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy- |
| 2-(3,4-Dimethoxyphenyl)-5-hydroxy-6,7,8-trimethoxy-4H-chromen-4-one |
| 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone |
| Demethylnobiletin |
| 5-O-Demethylnobiletin |
| 5-hydroxy-3',4',6,7,8-pentamethoxyflavone |
| 5-Demethylnobiletin |
| 5-desmethylnobeletin |
| 5-desmethylnobiletin |
2. Packaging
For powders: normal is 25kgs/Drum or bag, or larger/smaller package as request.
For liquids: normal 25kgs/drum, 180-300kgs/bucket, or IBC, determined by the nature of the product.
Or smaller package 1kg/bottle, 10kgs/bottle as request.
3. Shipping
4. Contact information
For more details, pls contact us freely.
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WhatsApp/Skype/Wechat/LINE: 86 13526505137
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