5-Bromo-2-fluorobenzonitrile NEW

2-fluoro-5-bromobenzonitrile is a white to off-white powder or crystal at room temperature and pressure, and is a common organic synthesis intermediate. 2-fluoro-5-bromobenzonitrile is soluble in dimethyl sulfoxide,N, N-dimethylformamide, dichloromethane, ethyl acetate and other organic solvents, but its solubility in water is poor.

Appearance and properties: white to off-white powder or crystal

Density: 2.089g/cm3

Boiling point: 260.3ºC at 760mmHg

Melting point: 76-81 °C

Flash point: 111.2ºC

Refractive index: 1.577

Steam pressure: 0.114mmHg at 25°C

Usage：

2-fluoro-5-bromobenzonitrile, as a common intermediate in organic synthesis, is mainly used to convert bromine atoms and fluorine atoms on the benzene ring to synthesize the molecular structure of the target. For example, bromine atoms can be Suzuki coupled to introduce an aromatic ring or an alkyl chain; Or to convert bromine atoms into boric acid or borate ester, using the borate diversity of Chemicalbook conversion ability to achieve the synthesis of complex molecules. Fluorine can also undergo a variety of transformations including aromatic nucleophilic substitution reactions. Finally, the cyanide group on the benzene ring can be easily converted into amide, ester group, carboxyl group and so on. Through selective regulation and coordination of these reactions, 1,2, 4-trisubstituted benzene derivatives can be prepared and synthesized rapidly.