5-Bromo-2-ethoxypyridine NEW

Product Description

Appearance and properties: light yellow crystal

Density: 1.449 g/cm3

Boiling point: 216.3ºC at 760 mmHg

Melting point: 32-36ºC

Flash point: 218

Refractive index: 1.534

Usage:Pharmaceutical and biochemical intermediates.

Application:

5-bromo-2-ethoxy-pyridine is a pyridine compound that can be used as an organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development processes and chemical production processes.

Preparation:

(1) Add 47g2, 5-dibromopyridine, 8g solid sodium hydroxide and 200ml ethanol into a 500ml reaction bottle, stir and start to 

heat up to the reflux state, the reaction time is 5 hours, stop the reaction, steam out most of the methanol, cool down, add 100ml water, extract the dichloromethane once, and remove the dichloromethane to obtain crude products. The crude product 

was distilled under vacuum to obtain 5-bromo-2-ethoxypyridine with a yield of 98%.

(2) Use 2, 5‑ dibromo-pyridine to treat the newly prepared sodium ethanolin solution in ethanol and heat reflux for 28 hours. The compound 5-bromo-2-ethoxypyridine (3 g, 70%) was obtained by concentrating the mixture and partially placing it in dichloromethane and water, washing the organic layer with salt water, drying with magnesium sulfate, filtering and evaporating under a vacuum strip. LCMS: 202.0[M+1]+

(3) 5-bromo-2-ethoxypyridine. Sodium hydride (14mmol, 330mg) was slowly added to ethanol (15ml) at 0℃. Stir the reactant for 30 minutes and add 5-bromo-2-chloropyrimidine (3.2mmol, 620mg). The reaction mixture was allowed to warm to room temperature overnight, then quenched with water and extracted with ethyl acetate. Combined with the organic layer, the required bromide (470mg, 72%) was obtained by vacuum concentration. MS(M+2)+203.4.

Packing

1kg/aluminium foil bag, with two plastic bags inside.

25kg/fiber drum, with two plastic bags inside.

≤50kg, Express delivery recommended, usually called as DDU service;

≤500kg,Air shipping recommended, usually called as CIF service;

>500kg, sea shipping recommended, usually called as FOB, CFR, or CIF service;

For high value products, please select air shipping and express delivery for safety.

Company Profile

Hebei yanxi chemical co.,Itd is a professional research and development of the production of lead acetate,2-phenylethylamide enterprises.The key members of the company are established by local well-known entrepreneurs and professional engineers under the call and support of the party's"low-carbon environmental protectionsafety and stability"under the innovation in traditional production equipment and technology,the use of"high temperature cooling"and "plastic basin crystallization"technology,on the basis of reducing the cost of products to make the quality of products to the same industryWith the efforts of all the staff of the companywe have established many cooperative companies in Shan Dong,He Nan,Guang Dong and other places in recent decades. Under the close supervision of the quality inspection department of the company,we carry out production and sales in the way of "labeling",providing the most convenient and fastest service for users all over the countryCompanies in the"advance with The Timesand the city every day with the advancement of"under the guidance of the core ideasadhering to the"relying on scientific and technological innovationthe development of circular economy" of the enterprise purpose,established in the marketenhance strength,go the way of science and environmental sustainable developmentrelying on the national technology research and development center, increasing spending on research and development based on the domestic market, expand the international marketmanufacturing high quality productssincere service society,toward a modern, ecology, science and technologychemical enterprises of the world.

Our Advantages

1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of many years. 

2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .

3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air. The most professional forwarder would be 

recommanded for you.

4. Fast delivery: We have stock, so we can delivery quickly once payment is received.

5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.

6. Competitive prices: A discount would be given when you make a large order.

FAQ

Q1: How can I place the order? 
A: You can send your requirement here on line,or send your purchase plan to us. We will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly. 
Q2: Can I test the quality before placing the order? 
A: Sure. Samples are available. You can buy samples to test the quality and there will be discount for samples. 
Q3: What's your MOQ? 
A: It depends on the products. Please feel free to contact our salesman. 
Q4: Is there a discount? 
A: Yes. For large quantity, we always offer better prices.