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ChemicalBook Product Catalog Biochemical Engineering Inhibitors Proteases Cysteine ??Protease Inhibitors MK-0822

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MK-0822

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No603139-19-1
Supply Ability100KG
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	MK-0822
CAS No	603139-19-1
EC-No
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

MK-0822 Basic information

Bioactivity In vitro In vivo Features

Product Name:	MK-0822
Synonyms:	Odanacatib,MK-0822,MK0822;Pentanamide, N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]-, (2S)-;(2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide Odanacatib (MK-0822);Odanacatib (2S)-N-(1-Cyanocyclopropyl)-4-fluoro-4-methyl-2-[[(1S)-2,2,2-trifluoro-1-[4'-(methylsulfonyl)[1,1'-biphenyl]-4-yl]ethyl]amino]pentanamide;(S)-N-(1-cyanocyclopropyl)-4-fluoro-4-methyl-2-((S)-2,2,2-trifluoro-1-(4'-(methylsulfonyl)biphenyl-4-yl)ethylamino)pentanamide;Odanacatib, >=98%;MK-0822;ODANACATIB
CAS:	603139-19-1
MF:	C25H27F4N3O3S
MW:	525.564
EINECS:	1533716-785-6
Product Categories:	API;Inhibitors
Mol File:	603139-19-1.mol

MK-0822 Chemical Properties

density

1.35

Safety Information

MSDS Information

MK-0822 Usage And Synthesis

Bioactivity	Odanacatib (MK-0822) is an effective and selective neutral inhibitor for cathepsin K(human /rabbit) and IC50 is 0.2 nM/1 nM. It has high selectivity for off-target cathepsin B， L， S. Phase 3。
In vitro	In vitro, Odanacatib acts on cathepsin K with high inhibitory activity and selectivity with IC50 of 0.2 nM and 1 nM when it acts on cathepsin K of human and rabbits. Odanacatib is also effective in all human enzyme experiments with IC50 of 5 nM.
In vivo	With a dosage of 10 mg/kg acting on preclinical rats, Odanacatib has good pharmacokinetic characteristics such as scavenging activity(Cl: 2 mL kg-1 min-1), low distribution (Vdss: 1.1 L kg-1), half-life(T1/2: 6 h) and Orally bioavailable (F: 8%).In addition, Odanacatib has a good metabolic stability if it acts on the Parental rats with 96% recovery of live. With the dosage of 9 µM, Odanacatib can significantly Increase the Proximal femur bone mineral density (BMD) (7.8%), femoral neck BMD (10.8%) and thighs greater trochanter BMD (6.5%). Long-term treatment with Odanacatib on skeletal matured macaque which is lack of estrogen can efficiently inhibit the bone metabolism, and will not reduce the number of osteoclast. It can also maintain the biomechanics properties of nonhuman primates with Ovary resection (OVX).
Features	Odanacatibis an effective and selective neutral inhibitor for cathepsin K

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