| Description |
Aceclofenac is a kind of orally administrated phenylacetic acid derivative with analgesic and anti-inflammatory properties. It can alleviate various kinds of painful conditions. It can reduce the pain, disease severity and improve the functional capacity of the knee. For patients with rheumatoid arthritis, it can reduce the joint inflammation, pain intensity and the duration of morning stiffness. It exerts effects on a variety of mediators of inflammation. It can block the synthesis of the inflammatory cytokines interleukin (IL)-1β and tumor necrosis factor, and inhibits prostaglandin E2 (PGE) production. Aceclofenac is well tolerated with most adverse events being minor and reversible. |
| Chemical Properties |
White Crystalline Solid |
| Uses |
Aceclofenac is an anti-inflammatory and analgesic drug. |
| Uses |
Relief of pain and inflammation |
| Uses |
Labeled Aceclofenac, intended for use as an internal standard for the quantification of Aceclofenac by GC- or LC-mass spectrometry. |
| Uses |
Anti-inflammatory; analgesic |
| Definition |
ChEBI: A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. |
| References |
Brogden, Rex N., and Lynda R. Wiseman. "Aceclofenac. A review of its pharmacodynamic properties and therapeutic potential in the treatment of rheumatic disorders and in pain management." Drugs 52.1 (1996): 113-124.
Raza, Kaisar, et al. "Topical delivery of aceclofenac: challenges and promises of novel drug delivery systems." BioMed research international 2014 (2014).
Dooley, Mukta, Caroline M. Spencer, and Christopher J. Dunn. "Aceclofenac: a reappraisal of its use in the management of pain and rheumatic disease." Drugs 61.9 (2000): 1351-1378. |
China
