| Description |
Fexofenadine hydrochloride (trade name: Allegra) belongs to a second-generation antihistamine pharmaceutical drug. It is mainly used for the treatment of allergy symptoms including watery eyes, hay fever, nasal congestion, urticaria, runny nose, itching eyes/nose, sneezing, hives, and itching. It is a kind of selectively peripheral H1 blocker. Its mechanism of action in vivo is through preventing the histamine-mediated activation of the H1 receptors, thus alleviating the symptoms related to allergy. Compared to the first-generation antihistamine drug, it is less prone to penetrate the blood-brain barrier, reducing the possibility to cause side effects such as drowsiness. |
| References |
http://www.rxlist.com/allegra-drug/consumer-uses.htm
https://en.wikipedia.org/wiki/Fexofenadine |
| Chemical Properties |
Off-White Crystalline Solid |
| Uses |
A metabolite of of terfenadine, a H1-Histamine receptor antagonist |
| Uses |
The active metabolite of Terfenadine (T114500), a H1-histamine receptor antagonist. |
| Uses |
Antihistaminic;histamine H1-receptor antagonist |
| Uses |
Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical] |
| Biological Activity |
Selective histamine H 1 receptor antagonist (pK i = 8.1). Active metabolite of terfenadine that displays non-sedating antiallergic effects. |
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