Basic information Description Treatment for Early-stage Breast Cancer Uses Pharmacokinetics Indications and Usage Clinical Research Safety Related Supplier

ChemicalBook Product Catalog API Antineoplastic agents Hormonal antineoplastic drugs Anastrozole

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Anastrozole

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No120511-73-1
Supply Ability100KG
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	Anastrozole
CAS No	120511-73-1
EC-No
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

Anastrozole Basic information

Indications and Usage Clinical Research

Product Name:	Anastrozole
Synonyms:	ICI-D-1033;ARIMIDEX;1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE;ANASTRAZOLE;ANASTROZOLE;tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile;ZD-1033;1,3-benzenediacetonitrile,alpha,alpha,alpha’,alpha’-tetramethyl-5-(1h-1,2,4-t
CAS:	120511-73-1
MF:	C17H19N5
MW:	293.36626
EINECS:	1806241-263-5
Product Categories:	Active Pharmaceutical Ingredients;Antineoplastic;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Anastrozole;API
Mol File:	120511-73-1.mol

Anastrozole Chemical Properties

Melting point	81-82°C
storage temp.	Store at RT
solubility	DMSO: soluble40mg/mL
InChIKey	YBBLVLTVTVSKRW-UHFFFAOYSA-N
CAS DataBase Reference	120511-73-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22-61-60
Safety Statements	26-37/39
RIDADR	3249
RTECS	CZ1465000
HazardClass	6.1(b)
PackingGroup	III
HS Code	29339980
Hazardous Substances Data	120511-73-1(Hazardous Substances Data)

Anastrozole Usage And Synthesis

Indications and Usage	Anastrozole is a potent selective triazole aromatase inhibitor that inhibits the aromatase that cytochrome P-450 is dependent on to prevent the biosynthesis of estrogen. Estrogen is the main stimulating factor for breast cancer cell growth. This drug’s half maximal inhibitory concentration (IC50) value to human placental aromatase is 15nmol/L. Compared to the traditional drug tamoxifen, Anastrozole can comprehensively and effectively lower the risks of breast cancer recurrence and metastasis, thus extending patients’ disease-free survival. Anastrozole is suitable for treating postmenopausal advanced breast cancer patients, especially postmenopausal advanced breast cancer patients who experienced recurrence following hormone assisted therapy.
Clinical Research	A series of clinical trials compared the effects of third generation aromatase inhibitor Anastrozole with those of tamoxifen. The trial was a global multicenter trial and includes 381 centers in 21 countries. Since 1996, there have been 9366 patients who have participated, and the follow-up time is 100 months. 25.8% of patients in the Anastrozole group experienced recurrence, while 29.9% of patients in the tamoxifen group did. Thus, Anastrozole’s recurrence rate was 4.1% lower than that of tamoxifen, and its risk of distant metastasis was lower as well. Anastrozole is also safer than tamoxifen.
Chemical Properties	Crystalline Solid
Uses	antiseptic, spermaticide
Uses	An aromatase inhibitor. Used as an antineoplastic.
Definition	ChEBI: A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position.
Biological Activity	Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.

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