Basic information description Uses Indications and Usage Adverse reactions Contradictions Safety Related Supplier

ChemicalBook Product Catalog API Hormones and the Endocrine System Estrogen and progestin drugs β-ESTRADIOL

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β-ESTRADIOL

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No50-28-2
Supply Ability100KG
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	β-ESTRADIOL
CAS No	50-28-2
EC-No
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

β-ESTRADIOL Basic information

Indications and Usage Adverse reactions Contradictions

Product Name:	β-ESTRADIOL
Synonyms:	BETA-ESTRADIOL-16,16,17-D3;17BETA-ESTRADIOL-16,16,17-D3;(+)-3,17β-estradiol;(17b)-estra-1,3,5(10)-triene-3,17diol;(17β)-estra-1,3,5(10)-triene-3,17diol;.alpha.-Oestradiol;.beta.-Oestradiol;17-.beta.-Estra-1,3,5(10)-triene-3,17-diol
CAS:	50-28-2
MF:	C18H24O2
MW:	272.38
EINECS:	200-023-8
Product Categories:	Steroids;Estrogen;Hormone;Analytical Chemistry;Biochemistry;Environmental Endocrine Disruptors;Estradiol, etc. (Environmental Endocrine Disruptors);Hydroxysteroids;Intracellular receptor;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;API;VIVELLE;Hormone Drugs;Inhibitors;powder or crystal
Mol File:	50-28-2.mol

β-ESTRADIOL Chemical Properties

Melting point	178-179 °C(lit.)
alpha	D25 +76 to +83° (dioxane)
Boiling point	355.44°C (rough estimate)
density	1.0708 (rough estimate)
refractive index	80.4 ° (C=1, Dioxane)
Fp	2℃
storage temp.	2-8°C
form	powder
color	White to off-white
Water Solubility	Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck	14,3703
BRN	1914275
Stability:	Stable. Incompatible with strong oxidizing agents.
InChIKey	VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference	50-28-2(CAS DataBase Reference)
NIST Chemistry Reference	Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System	Estra-1,3,5(10)- triene-3,17-diol (17.beta.)-(50-28-2)

Safety Information

Hazard Codes	T,Xn,F
Risk Statements	60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements	53-22-36/37/39-45-36/37-26-16-36-20
RIDADR	2811
WGK Germany	3
RTECS	KG2975000
F	8-10
HazardClass	6.1
PackingGroup	III
HS Code	29372390
Hazardous Substances Data	50-28-2(Hazardous Substances Data)

β-ESTRADIOL Usage And Synthesis

Indications and Usage	Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water. Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.
Adverse reactions	In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.
Contradictions	Do not use on breasts, vaginal area and vaginal mucosa.
Chemical Properties	White Crystalline Powder
Uses	Potent mammalian estrogenic hormone produced by the ovary.
Uses	Estradiol is the major estrogen secreted by the premenopausal ovary.
Definition	ChEBI: The 17beta-isomer of estradiol.
Biological Activity	Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

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