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ChemicalBook Product Catalog Alvespimycin

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Alvespimycin

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No467214-20-6
Supply Ability100KG
Update time2019-07-06

career henan chemical co

career henan chemical co

7YR

China

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Chemical Properties

Product Name	Alvespimycin
CAS No	467214-20-6
EC-No
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

Alvespimycin Basic information

Product Name:	Alvespimycin
Synonyms:	17-DIMETHYLAMINOETHYLAMINO-17-DEMETHOXYG;17-DMAGhydrochloride;17-[2-(Dimethylamino)ethylamino]-17-desmethylgeldanamycin;17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin;Alvespimycin;17-DMAG (Alvespimycin);17-DMAG;Unii-001L2fe0m3
CAS:	467214-20-6
MF:	C32H48N4O8
MW:	616.74552
EINECS:
Product Categories:	Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Isotope Labelled Compounds
Mol File:	467214-20-6.mol

Alvespimycin Chemical Properties

density	1.20
storage temp.	Desiccate at -20°C

Safety Information

MSDS Information

Alvespimycin Usage And Synthesis

Chemical Properties	Solid
Uses	17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
Uses	The labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
Definition	ChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.
Biological Activity	Water-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).

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