Basic information Safety Related Supplier

Alvespimycin

Basic information Safety Related Supplier
Alvespimycin Basic information
Alvespimycin Chemical Properties
  • Density 1.20
  • storage temp. Desiccate at -20°C
Safety Information
  • HS Code 29419090
Alvespimycin Usage And Synthesis
  • Chemical PropertiesSolid
  • Uses17-DMAG is an analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). 17-DMAG acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
  • UsesThe labelled derivative of the analogue of Gelamycin (G304500) and 17-(Allylamino)geldanamycin (A549650). It acts as a Hsp90 inhibitor and displays more potent antitumor activity than 17-AAG.
  • DefinitionChEBI: A 19-membered macrocyle that is geldanamycin in which the methoxy group attached to the benzoquinone moiety has been replaced by a 2-(N,N-dimethylamino)ethylamino group.
  • Biological ActivityWater-soluble analog of 17-AAG (17-Demethoxy-17-(2-propenylamino)geldanamycin ) and geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ). Binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG (mean GI 50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively).
Alvespimycin(467214-20-6)Related Product Information
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  • Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.
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  • Company Name:China DongFan Chemical Co.,LTD
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  • Company Name:Dalian Meilun Biotech Co., Ltd.
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  • Company Name:NCE Biomedical Co.,Ltd.
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