Irinotecan

$ 1.00 /1KG

Min. Order1G
Purity98%
Cas No97682-44-5
Supply Ability100KG
Update time2019-07-06

career henan chemical co

6YR

China

Chemical Properties

Product Name	Irinotecan
CAS No	97682-44-5
EC-No	1806241-263-5
Min. Order	1G
Purity	98%
Supply Ability	100KG
Release date	2019/07/06

AD68

Irinotecan Basic information

Product Name:	Irinotecan
Synonyms:	Irinotecan (free Base);Irinotecan(TECANS);1,4'-Bipiperidine-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14- tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester;DQ-2805;(4S)-4,11-Diethyl-4-hydroxy-9-[[(4-piperidinopiperidino)carbonyl]oxy]-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione;SN-38-11;(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.0^{2,11}.0^{4,9}.0^{15,20}]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate;(4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl-[1,4'-bipiperidine]-1'-carboxylic acid
CAS:	97682-44-5
MF:	C33H39ClN4O6
MW:	623.14
EINECS:	1806241-263-5
Product Categories:	Camptothecin series;APIs;Natural Anti-cancer Medical Materials and It's Derivatives;API's;API;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Camptosar, Campto;Anti-cancer&immunity;Anti cancer;Inhibitors
Mol File:	97682-44-5.mol

Irinotecan Chemical Properties

Melting point	222-223°
storage temp.	2-8°C
CAS DataBase Reference	97682-44-5(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn
Risk Statements	22
RTECS	DW1061000
Hazardous Substances Data	97682-44-5(Hazardous Substances Data)

MSDS Information

Irinotecan Usage And Synthesis

Uses

Irinotecan is a topoisomerase I inhibitor for LoVo cells and HT-29 cells with IC50 of 15.8 μM and 5.17 μM, respectively

Definition

ChEBI: A member of the class of pyranoindolizinoquinolines that is the carbamate ester obtained by formal condensation of the carboxy group of [1,4'-bipiperidine]-1'-carboxylic acid with the phenolic hydroxy group of (4S)-4,11-diethyl-4,9-dihydro y-1H-pyrano[3',4':6,7]indolizino[1,2- hydrochloride]quinoline-3,14-dione. Used (in the form of its hydrochloride salt trihydrate) in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcino a of the pancreas after disease progression following gemcitabine-based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active.