| 名称 | 4-Phenylbutyric acid |
| 描述 | 4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders. |
| 体外活性 | METHODS: ERp57 KO and control cells were treated with 4-Phenylbutyric acid (50 mM) and protein expression levels were detected by Immunoblot analysis.
RESULTS: Levels of ER stress marker proteins BiP, Chop and IRE1 were increased in ERp57 KO cells compared to control cells, indicating higher levels of ER stress in the absence of ERp57. 50 mM 4-Phenylbutyric acid treatment was effective in ERp57 KO cells and reduced protein levels of all three ER stress markers. protein levels of all three ER stress markers. In the case of IRE1, ER stress proteins were even reduced below the levels of control cells. [1]
METHODS: A549 cells and primary nasal epithelial cells were treated with 4-Phenylbutyric acid (0-20 mM) for 72 h. Cell viability was measured by MTT assay.
RESULTS: Cells were examined after treatment with 4-Phenylbutyric acid concentrations ranging from 0-20 mM, and cell survival was not affected below 10 mM. [2] |
| 体内活性 | METHODS: To study the effects on obese mice, 4-Phenylbutyric acid (120 mg/kg) was administered intraperitoneally to KK-Ay mice fed Lieber-DeCarli diet (5% EtOH) once daily for ten days. On day 11, a single dose of EtOH (4 g/kg) was administered by gavage.
RESULTS: In an obese mouse model, chronic overdose of EtOH induced massive ER stress-related oxidative stress and liver injury through dysregulation of unfolded protein responses. 4-Phenylbutyric acid ameliorated the liver injury induced by chronic addition of overdose of EtOH by decreasing ER and oxidative stress after overdose of EtOH. [3] |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (304.51 mM)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 12.5 mg/mL (76.13 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
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| 关键字 | 4-PBA | 4Phenylbutyric acid | 4-Phenylbutyric acid | Virus Protease | inhibit | Histone deacetylases | HDAC | Inhibitor | 4 Phenylbutyric acid |
| 相关产品 | EIDD-1931 | Phenytoin sodium | Valproic acid sodium salt | Panobinostat | Sodium 4-phenylbutyrate | Anthraquinone | 2-Phenylethanol | Curcumin | (-)-α-Pinene | Theophylline |
| 相关库 | 经典已知活性库 | 抗癌临床化合物库 | 抗病毒库 | 药物功能重定位化合物库 | 抑制剂库 | 抗癌上市药物库 | 抗衰老化合物库 | 古代经典名方目录分子库 | 抗癌药物库 | 抗癌活性化合物库 |
United States
