Hoyoshee offers CAS 137-00-8, 4-Methyl-5-thiazoleethanol, NLT99.5%- 99.9%, its formula is C6H9NOS,Its documents as NMR, MSDS, HPLC, COA for your needs.
4-Methyl-5-thiazoleethanol is utilized in the synthesis of novel HldE kinase inhibitors used against gram-negative bacteria. It is also used in the synthesis of potential antimalarial agents derived from bis-thiazolium analogues. This compound was originally isolated from the ether-soluble alkaloidal fraction of Panax ginseng. 4-Methyl-5-thiazoleethanol demonstrates the ability to inhibit the growth of certain wild-type bacterial strains. By binding to the bacterial cell membrane, it prevents the transport of nutrients into the cell, ultimately leading to a decrease in ATP synthesis and metabolic disorders. Additionally, 4-Methyl-5-thiazoleethanol inhibts caproic acid oxidation, potentially impacting cytosolic Ca2+ responses. 4-Methyl-5-thiazoleethanol exhibits a strong affinity for DNA and RNA, allowing it to be a good candidate for biochemical experiments involving these biomolecules. The specific binding site of 4-Methyl-5-thiazoleethanol is yet to be determined, it is hypothesized that this compound interacts with nucleic acids through electrostatic interactions or hydrogen bonding.
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