4-Iodoimidazole CAS 71759-89-2 | Core Supplier of Highly Active Iodinated Heterocyclic Intermediates
[Core Keywords]: 4-Iodoimidazole Supplier, CAS 71759-89-2, Iodinated Heterocyclic Pharmaceutical Intermediates, Photoinitiator Building Blocks
Product Basics
Chemical Name: 4-Iodo-1H-imidazole
CAS No.: 71759-89-2 (Title-Level Keyword Emphasis)
Molecular Formula: C₃H₃IN₂
Appearance: White to light-yellow crystalline powder
Purity: ≥98.0% (HPLC, pharmaceutical intermediate grade)
Key Physicochemical Properties (Structured Data Optimization)
| Attribute | Value |
|---|
| Molecular Weight | 209.97 g/mol |
| Melting Point | 155-158℃ (decomposes, DSC determination) |
| Solubility | Soluble in DMSO, DMF; slightly soluble in ethanol; insoluble in water |
| Stability | Light-sensitive (store in dark); stable at pH 6-8 |
| Storage Conditions | -20℃ in dark, under inert gas |
Upstream-Downstream Industrial Chain Integration
▶ Upstream Material Guarantee
Core Intermediates: Imidazole, iodinating reagents (N-Iodosuccinimide/NIS)
Process Optimization: Selective iodination technology (conversion >92%, byproducts <0.5%)
▶ Downstream Application Expansion
Antiviral Drugs: Key fragment for HCV NS5A inhibitors
Photosensitive Materials: Radical photoinitiators for UV-curable coatings
Organic Catalysis: Ligand precursor for Suzuki coupling reactions
Molecular Probes: Click chemistry substrates for protein iodination labeling
Industry Solutions & Technical Advantages
| Application Field | Typical Scenario | Technical Strengths |
|---|
| Antiviral Drugs | Daclatasvir analog synthesis | Iodine atom coupling yield >95% (LC-MS verified) |
| Photocuring Materials | 3D printing resin photosensitizer development | Photoinitiation efficiency (405nm) increased by 25% |
| Catalytic Chemistry | Pd-catalyzed C-C bond coupling optimization | Ligand activity TOF >500 h⁻¹ |
| Molecular Imaging | ¹²⁵I-radiolabeled antibody drug preparation | Iodination purity ≥99.5% |
SEO Keyword Matrix
Core Keyword Layout:
Long-Tail Keyword Combinations:
"HCV NS5A Inhibitor Intermediate Manufacturer"
"UV Photoinitiator Iodinated Raw Material Supplier"
"Pharmaceutical-Grade 71759-89-2 Producer"
Compliance Statement
✅ EINECS Status: Not listed (per ECHA database)
✅ REACH Progress: PPORD exemption (R&D compliance, exemption ID: EX-2023-XXXXX)
✅ Radiolabeling Support: Custom ¹²⁵I/¹³¹I isotope services available (special qualification required)
✅ Analysis Reports: Full documentation (HPLC, MS, elemental analysis)
Note: Technical parameters and compliance details are subject to final verification. Contact for custom synthesis or regulatory support.
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