Mildronate Pharmaceutical Intermediate Treat Coronary Artery Disease & Heart Problems CAS 76144-81-5
Meldonium may be used to treat coronary artery disease. These heart problems may sometimes lead to ischemia, a condition where too little blood flows to the organs in the body, especially the heart. Because this drug is thought to expand the arteries, it helps to increase the blood flow as well as increase the flow of oxygen throughout the body.
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Name: Mildronate
Synonyms: 2-(2-carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt ; 3-(2,2,2-trimethylhydrazine)propionate ; Mildonate ; 3-(2,2,2-Trimethylhydrazinium)propionate ; 2-(2-Carboxyethyl)-1,1,1-trimethyl Hydrazinium Inner Salt ; Meldomiun ; MET88 ; Quateri ; 3-(trimethylammonioamino)propanoate;
MF: C8H17NO5
MW: 207.2243
CAS: 76144-81-5
Molecular Structure:
Descriptions:
Meldonium is believed to exert its cardioprotective effects through its ability to cause vasodilation in the coronary arteries via increased nitric oxide synthesis, reducing blood glucose concentrations through increased oxidation of glucose and also by preconditioning the heart to handle ischaemic situations, among other effects. It also has been used to treat cerebral ischaemia. This is all done through its inhibition of carnitine synthesis.
Applications:
Meldonium has also been found to induce anticonvulsant and antihypnotic effects involving alpha 2-adrenergic receptors as well as nitric oxide-dependent mechanisms. This, in summary, shows that meldonium given in acute doses could be beneficial for the treatment of seizures and alcohol intoxication.
Meldonium is also used in cases of cerebral ischemia, ocular ischemic syndrome and other ocular disease caused by disturbed arterial circulation and may also have some effect on decreasing the severity of withdrawal symptoms caused by the cessation of chronic alcohol use.
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