Paracetamol, 4-Acetamidophenol, Acetaminophen CAS: 103-90-2
4-Acetamidophenol
CAS: 103-90-2
MF: C8H9NO2
MW: 151.16
EINECS: 203-157-5
Chemical Properties White Solid
Usage antiinfectant
Usage dispersing agent in liquid scintillation counting
Usage Analgesic; antipyretic
General Description Odorless white crystalline solid. Bitter taste. pH (saturated aqueous solution) about 6.
Air & Water Reactions Slightly soluble in water.
Reactivity Profile 4-Acetamidophenol is sensitive to light. Incompatible with strong oxidizers. .
Fire Hazard Flash point data for 4-Acetamidophenol are not available; however, 4-Acetamidophenol is probably combustible.
Biological Activity Cyclooxygenase inhibitor; may be selective for COX-3 (IC 50 values are 460, > 1000 and > 1000 μ M for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.
Paracetamol, 4-Acetamidophenol, Acetaminophen Usage:
1. Antipyretic analgesics, international non proprietary drug called Paracetamol. It is the most commonly used non anti-inflammatory antipyretic analgesic, antipyretic effect similar to aspirin, the analgesic effect is weak, no anti rheumatic effects of anti inflammation, is the best varieties of acetanilide drugs. Particularly suitable for carboxylic acid can not be used drugs patients. For the common cold, toothache embolism. Acetaminophen is intermediate in organic synthesis, hydrogen peroxide stabilizer, photographic chemicals.
2. Used as antipyretic, analgesic, anti rheumatic drugs.
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Tests
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Standards
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Results
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Appearance
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White or almost white ,crystalline powder.
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White,crystalline powder.
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Identification
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A:IR absorption
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Complies
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Complies
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B:UV absorption
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Complies
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Complies
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C:TLC
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Complies
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Complies
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Melting point
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168~172C
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169.0~170.9C
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Water
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Not more than0.5%
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0.08%
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Related substance
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Impurity(chloroacetanilide)not more than 10 ppm
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2ppm
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Impurity K(4-aminophenol)not more than 50 ppm
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15 ppm
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Impurity F(4-nitrophenol)not more than 0.05%
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Not detected
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any other impurity not more than 0.05%
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0.01%
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Total of other impurities not more than 0.1%
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0.02%
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Residue on ignition
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Not more than 0.1%
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0.05%
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Chloride
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Not more than 0.014%
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Less than 0.014%
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Sulfate
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Not more than 0.02%
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Less than 0.02%
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Sulfide
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Conforms
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Conforms
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Heavy metals
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Not more than 0.001%
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Less than 0.001%
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Free p-aminophenol
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Not more than 0.005%
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Less than 0.005%
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Limit of P-chloroacetanilide
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Not more than 0.001%
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Less than 0.001%
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Readily carbonizable substances
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Conforms
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Conforms
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Residual solvents
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Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5%
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0.08%
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Assay(anhydrous basis)
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99.0~101.0%
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99.6%
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Conclusion: Complies with USP34 / BP2011
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Atropine sulfate Application
Anticholinergic drugs, can relieve smooth muscle spasm, inhibit glandular secretion. For the stomach and duodenal ulcers, gastrointestinal tract, kidney, biliary colic, mydriatic examination and optometry, keratitis, iris eyelashes and anesthesia before administration, also used for organic phosphorus insecticide Of the poisoning, septic shock and antimony preparations caused by acute cardiogenic cerebral ischemia syndrome.
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4-Acetamidophenol 103-90-2 Pharmaceutical Raw Materials
4-Acetamidophenol 103-90-2 Pharmaceutical Intermediate
4-Acetamidophenol 103-90-2 Raw Chemical Product
4-Acetamidophenol 103-90-2 Supplier & manufactuer
China
