CAS 111470-99-6
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Product Name
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Amlodipine besilate
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Alias
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mono benzene sulfonate
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CAS
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111470-99-6
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MF
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C26H31ClN2O8S
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MW
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567.05
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Purity
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99%
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Appearance
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White Crystalline Solid
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Certification
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ISO 9001, USP, BP
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Standard
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BP Standard
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Usage
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A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive
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Packing
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Discreet packing ways as your requirement, 100% go through
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Storage
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Store in cool and dry area and keep away from direct sunlight
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Specification:
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Item
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Specification
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Result
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Appearance
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White or almost white powder
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Complies
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Identification
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IR spectrum is in conformance with that of RSThe retention time of the major peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the assay
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Complies
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Optical rotation
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-0.10°~+0.10°
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+0°
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Water
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≤0.5%
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0.10%
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Residue on ignition
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≤0.02%
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0.004%
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Related substances
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TLC method: any impurity ≤0.3%, at most 2 impurities more than 0.1%
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Complies
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HPLC method: amlodipine impurity A ≤0.3%
Total of other impurity ≤0.3%
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Impurity A=0.002%
Total of other impurity= 0.05%
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Residual solvent
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Ethanol ≤2000pm (loss on drying)
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500ppm
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Microbiological test
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Total aerobic microbial count: ≤1X10²CFU/g
Total molds and yeast count: 1X10²CFU/g
E.coli: absert(1g)
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10CFU/G
10CFU/G
Absent
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Assay
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97.0%~102.0%
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100.1%
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Conclusion
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The results conforms with USP31
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Use:
1.A dihydropyridine calcium channel blocker. Used as an antianginal and antihypertensive.
2.Angiotensin II inhibitor prodrug, antihypertensive.
3.Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
Description:
Amlodipine (generic name Amlodipine Besylate) is a class of calcium channel blockers.
Amlodipine functionalizes by the dilation of blood vessels and the improvement of blood flow, which lead to lowered blood pressure. Thereby, it is used to treat high bold pressure (hypertension). Lowering high blood pressure also reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions, and kidney problems. Amlodipine is also used to prevent certain types of chest pains (angina), which may help to increase the ability to exercise and decrease the frequency of angina attacks. Amlodipine can be used to treat coronary artery disease (CAD) including chronic stable angina, vasospastic angina, and angiographically documented CAD.
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
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Amlodipine besilate 111470-99-6 Pharmaceutical Raw Materials
Amlodipine besilate 111470-99-6 Pharmaceutical Intermediate
Amlodipine besilate 111470-99-6 Raw Chemical Product
Amlodipine besilate 111470-99-6 Supplier & manufactuer
China
