Chemical name: VORICONAZOLE
MF: C16H14F3N5O
MW: 349.31
CAS: 137234-62-9
Appearance: White powder
Usage: antifungal drug
COA:
Product name
Product name
|
Voriconazole |
CAS No.
|
137234-62-9 |
Outer Packing
|
1KG |
Production date
|
2016.04.04 |
Shelf life
|
2018.04.03 |
Standard adopted
|
USP36 |
Items of analysis
|
Specification
|
Results
|
| Appearance |
White or almost white crystalline powder |
white crystalline powder |
| Identification |
A.IR B.HPLC |
Conforms |
| Impurity C |
≤0.2% |
0.03% |
| Impurity D |
≤0.1% |
ND |
| unknown Impurity |
≤0.1% |
ND |
| Total impurity |
≤0.5% |
0.03% |
| Voriconazole Relatated Compound B |
≤0.2% |
ND |
| Voriconazole Relatated Compound F |
≤0.1% |
ND |
| Water |
≤0.4% |
0.18% |
| Residue on ignition |
≤0.1% |
0.06% |
| Heavy metals |
≤10ppm |
Conforms |
| Assay(HPLC) |
97.5-102% |
99.7% |
Conclusion
|
Qualified
|
Background:
Voriconazole (vor" i kon' a zole) is a synthetic triazole and a derivative of fluconazole, which is believed to act through inhibition of the fungal 14α-ergosterol demethylase that is responsible for converting lanosterol to ergosterol, which blocks cell membrane synthesis. Voriconazole has a broad spectrum of activity particularly against candida and aspergillus. Voriconazole was approved for use in the United States in 2002. Current indications include treatment of invasive aspergillosis, esophageal candidiasis and serious candidal infections. It is also used as empiric antifungal therapy in patients with neutropenia and persistent fever as well as preventive antifungal therapy in high risk individuals. Voriconazole is available as tablets of 50 and 200 mg, in an oral suspension (40 mg/mL) and in a parenteral formulation generically and under the brand name Vfend. Serious fungal infections are typically treated initially with intravenous voriconazole (4 to 6 mg/kg every 12 hours) for 3 to 10 days, followed by more prolonged therapy with oral forms (20 mg every 12 hours). Common side effects include nausea, photosensitivity, hallucinations, headache, visual disturbances and rash.
Medical uses:
Voriconazole is used to treat invasive aspergillosis andcandidiasis and fungal infections caused by Scedosporium and Fusarium species, which may occur in immunocompromised patients, including people undergoing allogeneic bone marrow transplant (BMT), who have hematologic cancers or who undergo organ transplants.
It is also used to prevent fungal infection in people as they undergo BMT.
It is also the recommended treatment for the CNS fungal infections transmitted by epidural injection of contaminated steroids.
It can be taken by mouth or given in a doctor's office or clinic by intravenous infusion.
Advantages:
Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.
1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.
2 . Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.
3 . Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate
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VORICONAZOLE 137234-62-9 Pharmaceutical Raw Materials
VORICONAZOLE 137234-62-9 Pharmaceutical Intermediate
VORICONAZOLE 137234-62-9 Raw Chemical Product
VORICONAZOLE 137234-62-9 Supplier & manufactuer
China
