Tetracaine HCl Quick Detail:
| Product Name |
Tetracaine Hydrochloride,Tetracaine HCL |
| Alias |
Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride;
4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride |
| CAS NO |
136-47-0 |
| EINECS |
205-248-5 |
| Molecular Formula |
C15H25ClN2O2 |
| Molecular Weight |
300.82 |
| MS |
99% USP 136-47-0 Tetracaine HCl/Tetracaine Hydrochloride |
| Melting Point |
149° C |
| Assay |
99% |
| Grade |
Medicine Grade |
| Storage |
Closed, confined and shading preservation |
| Usage |
Local anesthetic; Mainly used in mucosa anesthetic.
The function is stronger than Procaine and Lidocaine. |
Tetracaine HCl Description:
Tetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.
Tetracaine HCl Application:
Tetracaine hydrochloride (INN, also known as amethocaine; trade name Pontocaine. Ametop and Dicaine) is a potent local anesthetic of the ester group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
Tetracaine hydrochloride,In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.
Tetracaine HCl Usage:
Tetracaine hydrochloride is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum and Tetracaine hydrochloride is used for spinal anesthesia.
Tetracaine HCl COA :
| Test Items |
Specification |
Test Results |
| Appearance |
Fine, white, crystalline, odorless powder |
confirm |
| Identification |
ABC in Pass |
confirm |
| Solubility |
Very soluble in water, soluble in Alcohol;
insoluble in Ether and Benzene |
confirm |
| USP Reference standards |
USP Tetracaine Hydrochloride RS.
USP Endotoxin RS. |
confirm |
| Melting point |
145~150 degree |
146.0~147.5
degree |
| Chromatographic purity |
In Pass |
confirm |
| Related substance |
Not more than the reference solution 0.05% |
confirm |
| Heavy metals |
≤10ppm |
confirm |
| PH |
4.5-6.5 |
5.8 |
| Residue on ignition |
≤0.10% |
0.05% |
| Loss on Drying |
≤ 0.5% |
0.19% |
| Assay |
98.0 -101.0% |
100.1% |
| Conclusion |
Confirms USP 32 |
Advantages:
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136-47-0 Tetracaine HCL Pharmaceutical Raw Materials
136-47-0 Tetracaine HCL Pharmaceutical Intermediate
136-47-0 Tetracaine HCL Raw Chemical Product
136-47-0 Tetracaine HCL Supplier & manufactuer
China
